摘要
目的分析抗精神病类药物对精神分裂症患者心脏功能的影响。方法随机将本院收治的精神分裂症患者120例分为A、B、C三组,每组各40例。A组患者采用利培酮治疗,B组患者采用富马酸喹硫平片治疗,C组患者采用齐拉西酮治疗,比较三组患者治疗前后心电图QT间期、T波异常、ST-T压低以及左室舒张末内径等指标的变化情况。结果治疗前,三组患者QT间期值,窦性心动过速、T波改变及ST-T压低发生例数比较差异无显著性(P>0.05);与本组治疗前比较,治疗后三组患者QT间期均延长,T波改变、ST-T压低、窦性心动过速的发生例数均明显增加,差异具有显著性(P<0.05);治疗后C组QT间期延长更明显,窦性心动过速、T波改变、ST-T压低发生例数明显增多,与A组比较差异具有显著性(P<0.05)。三组患者治疗前左室舒张末内径、射血分数比较差异均无显著性(P>0.05);治疗后三组患者上述指标均得到明显改善,差异具有显著性(P<0.05);治疗4周后,C组患者较A组左室舒张末内径、射血分数明显更低,差异具有显著性(P<0.05)。结论抗精神病类药物均会对精神分裂症患者的心功能产生明显的影响,利培酮、富马酸喹硫平片对心脏产生的不良影响较齐拉西酮小。
Objective Study of schizophrenic patients with antipsychotic drugs treatment on the electrocardiogram（ECG） and cardiac ultrasound examination results. Method Our hospital randomly 120 patients with schizophrenia were divided into group A, B,and C, 40 cases in each group, group A were treated with risperidone, and group B with quetiapine fumarate tablets treatment, group C were treated with ziprasidone treatment, compared the changes of three groups of QT intervals of ECG, T wave before and after treatment in patients with abnormal ST-T down, and echocardiography, left ventricular end diastolic diameter index. Result Before treatment, three groups of patients with QT intervals, sinus Heartbeat and changes of ST-T wave speed, T the number of cases of depression had no significant difference（P〉0.05）. Compared with the group before treatment, after treatment, three groups of patients with prolonged QT interval, T wave changes, ST-T depression, sinus Heartbeat occurred in the number of cases were significantly increased inspeed, the difference was significant（P〈0.05）; after treatment, group C after prolonged QT interval was more obvious, sinus tachycardia, Heartbeat changes of T wave, ST-T depression occurred in the number of cases increased significantly, compared with group A, the difference was significant（P〈0.05）; the left ventricular end diastolic diameter, ejection fraction, comparison of the difference between three groups of patients were not significant（P〉0.05）. Compared with before treatment, after treatment the patients in the three groups of the above indicators were obviously improved（P0.05）, after four weeks of treatment, patients in group C than in group A left ventricular end-diastolic diameter, ejection fraction was significantly lower（P〈0.05）. Conclusion All have a significant impact on the heart function of patients with the spirit of using antipsychotic drugs in schizophrenia treatment, risperidone, quetiapine fumarate tablets less adverse effects on the heart
出处
《中国医学前沿杂志（电子版）》
2014年第11期97-99,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
精神分裂症
抗精神病类药物
心电图
心脏超声
Schizophrenia
Antipsychotic drugs
Electrocardiography
Echocardiography
