摘要
目的:探讨参附注射液对食道癌根治术所致肺损伤的保护作用。方法:60例限期行食道癌根治术患者,随机分为参附注射液组(n=30)和对照组(n=30)。于麻醉诱导后参附注射液组按1 m L/kg静脉给予参附注射液,对照组给予等容量的生理盐水。于单肺通气开始时(T0)、单肺通气1 h(T1)、恢复双肺通气3 h时(T2)各监测时间点抽取动脉血5 m L,用酶联免疫吸附法(ELISA)法测定血浆中白介素6(IL-6)、白介素8(IL-8)和肿瘤坏死因子α(TNF-α)的浓度。结果:两组患者T1、T2时点的血浆IL-6、IL-8和TNF-α的水平均较T0明显升高(P<0.05)。参附注射液组在T2时点的血浆IL-6、IL-8水平以及T1、T2时点的血浆TNF-α水平均明显低于对照组(P<0.05)。结论:参附注射液减轻了食道癌根治术单肺通气期间及其后血浆炎症因子IL-6、IL-8和TNF-α的水平,减轻了炎症反应。
Objective： To investigate the clinical effects of Shenfu injection（SF） on inflammatory response after esophagectomy.Methods： 60 Patients ready for esophagectomy were divided into two groups randomly, each group consisting of 30 cases. In Shenfu injection（SF） group, patients were given 1 mL/kg Shenfu injection after anesthesia induction. In control group, patients were given normal saline of equal volume after anesthesia induction. Plasma IL-6, IL-8 and TNF-α levels were measured at baseline（T0）, 1 h after one lung ventilation（T1） and 3 h after lung reinflation（T2）. Results： Compared with baseline level, plasma IL-6, IL-8 and TNF-α levels at T1, T2 point were both increased（P〈0.05）. Compared with the control group, patients in SF group had reduced plasma IL-6, and IL-8 level at T2 point, and reduced TNF-α at both T1 and T2point（P〈0.05）. Conclusion： Shenfu injection can reduce plasma IL-6, IL-8 and TNF-α levels after esophagectomy while minimizing inflammation.
出处
《实用中西医结合临床》
2014年第12期3-4,6,共3页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金
四川省教育厅科研基金(编号:14ZB0151)
四川省泸州市科技局科研基金(编号:2014S45)
