摘要
目的探讨粳米、籼米、小米米汤的止泻作用及其止泻机制。方法制备番泻叶致小鼠急性腹泻模型和新斯的明致小鼠小肠运动亢进模型,分别评价粳米、籼米、小米米汤对小鼠腹泻次数、小肠推进率的影响,考察不同浓度粳米米汤的止泻作用。结果与模型对照组比较,3种米汤均能不同程度对抗番泻叶致小鼠腹泻(P<0.05或P<0.01),粳米、籼米和小米对新斯的明小鼠小肠推进率分别为(61.7±15.6)%,(72.8±13.9)%,(71.3±21.2)%;大、中、小剂量粳米汤对新斯的明小鼠小肠推进率分别为(58.8±11.4)%,(63.1±12.9)%,(72.3±5.8)%,对正常小鼠小肠推进率分别为(68.2±6.1)%,(65.7±7.2)%,(64.4±6.8)%。结论 3种米汤都有不同程度的止泻作用,尤以粳米米汤作用显著,其止泻作用可能是通过抗胆碱作用产生。
Objective To investigate antidiarrheal effects of polished round-grained rice soup, long-shaped rice soup and millet soup, and the possible mechanism. Methods Acute diarrhea mouse models were established by feeding with folium seunae, and intestine sthenie movement mouse models were prepared with neostigmine. Effect of the three kinds of soup on diarrhea frequency and propelling rate of small intestine was observed, and the antidiarrheal effect of different concentrations of polished round-grained rice soup were further studied. Results Three rice soup significantly alleviated folium sennae-indueed diarrhea and lessened propulsion of small intestine induced by neostigmine （P〈0.05 or P〈0.01 ）. Propelling rate of intestine sthenic movement mouse prepared with neostigmine of polished round-grained rice soup, long-shaped rice soup and millet soup were （ 61.7_± 15.6 ） % , （ 72.8 _± 13.9 ） % , （ 71.3 ± 21.2 ） % ; Propelling rate of intestine sthenic movement mouse prepared with neostigmine of high, medium and low dose of polished round-grained rice soup were （58.8± 11.4） % , （63.1± 12.9） % , （72.3± 5.8 ） % ; Propelling rate of normal mouse of high, medium and low dose of polished round- grained rice soup were （ 68.2 ± 6.1 ） % , （ 65.7 ± 7.2 ） % , （ 64.4 ± 6.8 ） %. Conclusion Three rice water has significant antidiarrheal effects, especially iaponica rice shows the strongest activity, and it may exert antidiarrheal effects via cholinolvtie activity.
出处
《医药导报》
CAS
2015年第2期170-173,共4页
Herald of Medicine
基金
成都医学院大学生创新性实验项目(CX201208)
四川省大学生创新性实验项目
关键词
米汤
腹泻
小肠推进
粳米
Rice soup
Diarrheal
Propulsion of small intestine
Polished round-graied rice
