摘要
目的:观察梅花针叩刺联合活血解毒中药用于治疗尼妥珠单抗联合化疗过程中反应性药疹,以期为更好的提高晚期肿瘤患者药物依从性及生活质量提供论据支持。方法:90例晚期肿瘤患者均接受尼妥珠单抗联合其他化疗药的治疗,2周后评价按RECIST标准实体瘤情况,并根据是否产生药疹将其随机分为实验组及对照组。实验组行梅花针局部叩刺联合白花蛇舌草、苦参等活血解毒药物进行干预,对照组行生理盐水干预。经过2周与6周的综合治疗再次评估药疹变化情况;药疹标准参考加拿大国立癌症研究所扩大通用性标准(NCIC GTG分级)。结果:56例有药疹发生,且其实体瘤评估控制率与有效率与无药疹发生病例无明显差别;进一步评估56例入组药疹患者不同处理后药疹的变化情况,随机分成2组每组各28人,分中医外治干预组及空白对照组。治疗2周:出疹的患者实验组1级药疹率50‰2级39.3%,3级10.7%,实验组药疹情况控制于1级(◆P<0.05),实验组2级、3级药疹的发病率显著低于对照组(◆P<0.05)。治疗6周:实验组出现1级药疹35.7%,2级50%,3级14.3%;对照组3级42.9%,4级14.3‰实验组药疹控制在1级与2级(◆P<0.05),3级药疹的发病率显著低于对照组(★P<0.05)。结论:本研究表明,药疹与尼妥珠单抗药效无明显对应关系,同时活针药结合法可显著改善由于尼妥珠单抗联合化疗产生的药疹。
Objective： To observe the effect ofpercussopunctator combined with Herbs （promoting blood circulation and detoxication, Huo-Xue-Jie-Du） on epispasis induced by Nimotuzumab combined with Chemotherapy. The aim of this study is to improve the drug dependence and their life quality of advanced cancer patients. Method： We selected 90 patients who received the combined therapy of Nimotuzumab ＆ Chemotherapy. The solid tumor was detected by RECIST standard, and the epispasis patients would be separated into two groups, experimental group vs controls. The experimental group was to intervened with percussopunctator combined with Herbs, such as oldenlandia diffiasa, sophora flavescens air et al. The controls were intervened with physiological saline. 6 weeks later, solid tumor and the epispasis was detected according to NCIC GTG Results： 56 patients suffered epispasis, while the solid statue was no different. We fttrther treated the epispasis by Chinese medicine. Both the experimental group and the control group have 28 patients. 2 weeks： The epispasis of experimental group was 50%, second epispasis 39.3%, third ＇degree 10.7%; first degree epispasi was more in experimental group （◆P〈 0.05） ; compared with controls, second and third degree epispasis was lower （◆P〈0.05）. 6 weeks： The first degree epispasis of experimental group was 35.7%, second epispasis 42.9%, third degree 14.3%; first and second degree epispasi was more in experimental group （◆P〈0.05）. Compared with controls, third degree epispasi was lower in experimental group （★P〈0..05）; and there was no fourth degree.. Concliasion： There is no direct connection between epispasis induced by Nimotuzumab; the treatment of percussopnnctator combined with Herbs got its effect on epispasis induced by Nimotuzumab combined with Chemotherapy.
出处
《中医临床研究》
2015年第3期62-65,共4页
Clinical Journal Of Chinese Medicine
基金
国家自然科学基金-青年科学基金项目(81102678)
关键词
尼妥珠单抗
药疹
梅花针
活血解毒法
Nimotuzumab
Epispasis
Percussopunctator
Promoting blood circulation and detoxication
