摘要
目的探讨运用阿立哌唑与利培酮治疗精神分裂症的临床疗效。方法选择2013年4月至2014年3月我院收治的精神分裂症患者共70例,将其随机分为阿立哌唑组和利培酮组,每组各35例,两组均连续治疗8周,比较两组患者治疗后临床疗效以及治疗期间的不良反应。结果阿立哌唑组治疗总有效例数为32,总有效率为91.43%,利培酮组治疗总有效例数为31,总有效率为88.57%,两组比较,差异不具有统计学意义(P>0.05);利培酮组的震颤、静坐不能、体重增加以及月经改变或者泌乳的发生率分别为34.29%,28.57%,25.71%,25.71%,均显著高于阿立哌唑组的8.57%,8.57%,2.86%和0,差异具有统计学意义(P<0.05)。结论阿立哌唑和利培酮在治疗精神分裂症时疗效显著,且临床疗效相似,但是阿立哌唑的不良反应发生率较低,因此在精神科临床治疗当中推荐优先选用阿立哌唑作为抗精神分裂药物。
Objective To investigate and compare the clinical effect of aripiprazole and risperidone in the treatment of schizophrenia. Methods 70 cases of patients with schizophrenia admitted in our hospital from April 2013 to March 2014 were selected as objects. All the patients were randomly divided into aripiprazole group and risperidone group, with 35 cases in each group. Two groups were all treated for 8 weeks in different administer, one group was given aripiprazole, the other group was given risperidone, the clinical efficacy and adverse reactions of two groups were compared before and after the treatment. Results The total effective rate of the aripiprazole group was 91.43% （32/35）, the total effective rate of the risperidone group was 88.57% （31/35）, the difference of two groups was not statistical （P〉0.05）; the tremor, acathisia, weight gain, menstrual changes and lactation incidence of the risperidone group were 34.29%, 28.57 %, 25.71%, 25.71% respectively, significantly higher than 8.57%, 8.57%, 2.86% and 0 of the aripiprazole group, with statistical significant difference （P〈0.05）. Conclusions The application of aripiprazole and risperidone in the treatment of schizophrenia has obvious clinical curative efficacy and similar clinical curative efficacy, but the adverse reactions rate of aripiprazole is lower compared with the risperidone, so we should give priority to aripiprazole as antipsychotics in clinic.
出处
《临床医学工程》
2014年第12期1583-1584,共2页
Clinical Medicine & Engineering
