摘要
难愈性皮肤创面是指在期望的时间内不能正常愈合的皮肤组织创面。本文以表皮干细胞(ESC)为靶点,对其在难愈性皮肤创面愈合中的研究和应用进行综述。首先介绍ESC的解剖位置和对创面愈合的调节作用。其次,总结难愈性皮肤创面的特点及共同的病理学机制。最后,归纳ESC在难愈性皮肤创面愈合中的作用:直接修复损伤皮肤组织;作为组织工程学构建人工皮肤的种子细胞;以及其基因修饰治疗用于皮肤创面修复。
Non healing skin wound means that the course of wound healing was long beyond normal time. The research and application of epidermal stem cell （ESC）in non healing skin wound was reviewed in this paper. Firstly, the anatomy and regulation of ESC on wound healing were introduced. Secondly, the characteristics and general pathophysiological mechanism of non healing skin wound were summarized. At last, the mechanism of ESC in non healing skin wound was included： ESC can repair the skin tissue directly. ESC can be the seed cell of manufactured skin by histology engineering. The skin wound can be treated by the modified gene of ESC.
出处
《中华损伤与修复杂志（电子版）》
CAS
2014年第6期67-69,共3页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
关键词
干细胞
皮肤
难愈性创面
Stem cells
Skin
Non healing wound
