摘要
目的探讨儿童肥胖与高尿酸血症的相关性。方法选取于该院就诊的2~17岁肥胖儿童316例作为肥胖组。另随机选取年龄及性别与之相匹配且体质量指数（BMI）正常的于本院进行健康体检且合格的儿童316例作为对照组。抽取空腹静脉血检测尿酸、葡萄糖（GLU）、总胆固醇（CHOL）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。结果与对照组儿童比较,肥胖组儿童的尿酸、CHOL、TG、LDL-C水平均增高,而HDL-C水平降低,差异有统计学意义（P〈0.05）。肥胖组中,高尿酸血症的检出率为24.68%,而对照组为9.49%,差异有统计学意义（P〈0.05）。血尿酸水平与TG、CHOL、LDL-C水平呈正相关,与HDL-C呈负相关。结论肥胖可导致儿童血尿酸水平升高、血脂代谢异常。血尿酸水平与脂代谢异常具有相关性。
Objective To investigate the correlation between hyperuricemia and obesity in children.Methods 316 children who went to the hospital for treatment of obesity were enrolled in the study as obesity group.Age and sex-matched children with normal body mass index（BMI）were randomly recruited as control group.Fasting venous blood samples were collected for the detection of serum uric acid（UA）,glucose（GLU）,total cholesterol（CHOL）,triacylglycerol（TG）,high-density lipoprotein cholesterol（HDL-C）and low-density lipoprotein cholesterol（LDL-C）.Results Compared with the control group,serum concentrations of UA,CHOL,TG and LDL-C were higher while HDL-C was lower in obese children,the difference was statistically significant（P〈0.05）.The detection rate of hyperuricemia in obese children was 24.68%,and in control group was 9.49%,the difference was statistically significant（P〈0.05）.Serum UA concentration was positively correlated with TG,CHOL and LDL-C,negatively correlated with HDL-C.Conclusion Obesity can lead to higher serum UA concentration and abnormal lipid metabolism.The level of serum UA was correlated with abnormal lipid metabolism.
出处
《国际检验医学杂志》
CAS
2015年第3期322-323,共2页
International Journal of Laboratory Medicine
关键词
肥胖
高尿酸血症
高脂血症
儿童
obesity
hyperuricemia
hyperlipidaemia
children
