摘要
目的:探讨血浆同型半胱氨酸(Hcy)水平对原发性高血压患者发生冠心病的预测价值。方法:原发性高血压患者251例,根据冠脉造影结果分为单纯性高血压组(A组)和高血压合并冠心病组(B组),检测2组患者血浆Hcy、血糖、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、血尿酸、肌酐以及尿素氮水平,比较不同Hcy水平患者冠心病的发病率,通过logistic回归分析原发性高血压患者发生冠心病的危险因素。结果:A组患者血浆Hcy水平和低密度脂蛋白水平低于B组患者,而高密度脂蛋白水平高于B组患者,差异有统计学意义(P<0.05);血浆同型半胱氨酸水平(OR=4.503,P<0.05)和低密度脂蛋白水平(OR=3.509,P<0.05)是原发性高血压发生冠心病的独立危险因素;高密度脂蛋白可以降低原发性高血压患者发生冠心病的风险(OR=0.439,P<0.05)。结论:血浆同型半胱氨酸水平升高的患者发生冠心病的可能性大。
Objective： To explore the value of homocysteine （Hcy） levels in predicting the occur- rence of coronary heart disease （CHD） in patients with essential hypertension. Methods： Based on the results of coronary angiography, 251 patients with essential hypertension were divided into two groups as essential hypertension group （group A） and essential hypertension with CHD group （group B）. Levels of Hey, blood glucose, serum total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, blood uric acid, creatinine, urea nitrogen were detected, and the incidences of CHD in essential hypertension patients with different Hcy levels were compared. The logistic regression model was used to analyze the risk factors for occurrence of CHD. Results： The levels of Hey and low density lipoprotein in group B were higher than those in group A, while high density lipoprotein level was lower than that in group A （P 〈 0.05 ）. The levels of Hcy （ OR = 4. 503, P 〈 0.05 ） and low density lipoprotein（ OR =3.509,P 〈0.05）were independent predictors of CHD in patients with essential hy- pertension, while high density lipoprotein can decrease the incidence of CHD in patients with essential hypertension （OR = 0. 439, P 〈 0.05 ）. Conclusion： CHD is more likely to occur in essential hyperten- sion patients with high Hey levels
出处
《贵阳医学院学报》
CAS
2015年第1期97-99,103,共4页
Journal of Guiyang Medical College
关键词
高血压
冠心病
同型半胱氨酸
预测
血浆
hypertension
coronary heart disease
homocysteine
prognosis
plasma
