摘要
目的:考察灯盏花素微乳的相图制备及其性质。方法:分别以油酸(OA)、肉豆蔻酸异丙酯(IPM)、棕榈酸异丙酯(IPP)为油相;聚山梨酯80、聚氧乙烯蓖麻油(Cremop Hor EL-35)、聚氧乙烯氢化蓖麻油(Cremop Hor RH-40)为表面活性剂;无水乙醇、1,2-丙二醇、异丙醇为助表面活性剂;枸橼酸缓冲盐为水相,考察不同油相、表面活性剂、助表面活性剂之间的配比变化,并以微乳的区域为指标,通过伪三元相图,对微乳处方进行优化。结果:优化处方为3%肉豆蔻酸异丙酯,28.6%聚氧乙烯蓖麻油/无水乙醇/1,2丙二醇(4∶1∶1,Km=2∶1),68.4%枸橼酸缓冲液(p H 6.2),灯盏花素0.5%。微乳平均粒径为22.03 nm,多分散指数为0.381,电导率(1.897±0.132 4)ms·cm-1,Zeta电位-10.46 m V。结论:该处方设计合理,能得到符合要求的稳定微乳。
OBJECTIVE To investigate the preparation of breviscapine microemulsion phase diagrams and its property. METHODS The oil phase consisted of oleic acid（OA）, isopropyl myristate（IPM） and isopropyl palmitate（IPP）, the surfactant composed Of Tween-80, Cremophor Rh-40 and Cremophor El-35, the co-surfactant consisted of absolute alcohol, 1,2-propanediol and isopropyl, the aqueous phase was citric acid buffer solution, Pseudo-ternary phase diagrams were constructed to optimize the microemulsion formulation. RESULTS The optimized formulation was as follows.. IPM 3%（g/g）, Cremophor 28. 6% （g/g） / ethanol/1,2-propanediol （4：1 ： 1 ,Km = 2： 1） ,citric acid buffer solution 68. 4% （g/g） （pH 6. 2） and breviseapine 0. 5% （g/g） . Breviscapine microemulsion showed spherical shape. The mean particle sizes were 22. 03 nm, polydispersity index was 0. 381, electrical conductivity was （1. 897 ± 0. 1324） ms. cm^- 1 and Zeta-potential was - 10. 46 mV. CONCLUSION The prescription design is reasonable, can meet the requirements of the stability of the microemulsion.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第24期2131-2134,2157,共5页
Chinese Journal of Hospital Pharmacy
关键词
灯盏花素
微乳
伪三元相图
breviscapine
mieroemulsion pseudo-ternary phase diagram
