摘要
目的:探讨老年冠心病患者血小板-白细胞聚集体(PLA)的表达及其意义。方法 :选择我院内科2010年1月至2012年12月期间收治的冠心病患者162例,分为稳定型心绞痛(SAP)组(92例),急性冠脉综合征(ACS)组(70例),选择同期非冠心病患者80例为正常对照组。比较3组间PLA、血小板-中性粒细胞聚集体(PNA)、血小板淋巴细胞聚集体(PLyA)和血小板-单核细胞聚集体(PMA)的水平,采用Spearman相关分析分析PLA与有关临床指标的相关性。结果:与正常对照组和SAP组比较,ACS组PLA[(2.23±1.20)%比(3.25±2.16)%比(4.36±2.65)%]、PMA[(15.3±7.6)%比(23.5±19.7)%比(32.4±19.6)%]、PNA[(1.85±0.89)%比(2.14±1.56)%比(3.64±4.65)%]和PLyA[(1.38±0.78)%比(1.42±0.87)%比(2.06±1.28)%]水平显著升高(P均<0.01),且SAP组PLA、PMA水平显著高于正常对照组(P<0.01)。Spearman相关性分析显示:冠心病患者PLA与血糖、甘油三酯呈正相关(r1=0.680,P1=0.030;r2=0.738,P2=0.015),与高密度脂蛋白胆固醇呈负相关(r=-0.722,P=0.018)。结论:PLA、PMA水平升高提示可能有老年冠心病,甚至是急性冠脉综合征。
Objective： To investigate expression of platelet-leukocyte aggregates （PLA） and its significance in aged patients with coronary heart disease （CHD）. Methods.- A total of 162 CHD patients, who visited to our hospital from Jan 2010 to Dec 2012, were divided into stable angina peetoris （SAP） group （n ： 92） and acute coronary syndrome （ACS） group （n = 70）. Another 80 patients without CHD were selected as normal control group. Levels of PLA, platelet-neutrophil aggregates （PNA）, platelet lymphocyte aggregates （PLyA） and platelet-monocyte aggregates （PMA） were compared among three groups. Spearman correlation analysis was used to analyze the correlation a- mong relative indexes and PLA. Results~ Compared with normal control group and SAP group, there were signifi- cant rise in levels of PLAE （2.23± 1.20）% vs. （3.25±2.16）% vs. （4. 36±2.65）%], PMA[ （15. 3±7. 6）% vs. （23.5±19.7）% vs. （32.4±19.6）%], PNA[（1.85±0.89）% vs. （2.14±1.56）% vs. （3.64±4.65）%] and PLyA [- （1.38 ± 0.78） % vs. （1.42 ± 0.87） % vs. （2.06 ± 1.28） %] in ACS group, P〈0, 01 all, and PLA and PMA levels in SAP group were significantly higher than those of normal control group （P〈O. 01）. Spearman correlation analysis indicated that PLA was positively correlated with blood glucose and triglyceride （rl = 0. 680, P~ -- 0. 030 r2 -- 0. 738, Pz = 0. 015）, and inverse, ly correlated with HDL-C （ r = - 0. 722, P = 0. 018） in CHD patients. Conclusion： In- creased PLA and PMA levels indicate that there may be CHD disease, even acute coronary syndrome.
出处
《心血管康复医学杂志》
CAS
2014年第6期630-633,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
冠心病
血小板活化
血小板聚集
Coronary dis ease
Platelet activation
Platelet aggregation
