摘要
目的探讨剖宫产围手术期使用抗菌药物对新生儿高胆红素血症的影响。方法选择253例剖宫产产妇,根据抗菌药物不同用药方法分为对照组(n=130例,仅在术后采用2.0 g头孢唑林钠加入0.9%氯化钠注射液250 m L中静脉滴注,2次/日,连续用药3 d)和观察组(n=123例,在术前预防性使用1.0 g头孢唑林钠加入0.9%氯化钠注射液100 m L中静脉滴注,术后予以同等剂量静脉滴注,间隔8 h,共3次),比较两组高胆红素血症发生率、热病率及经济学差异。结果两组白细胞总数(WBC)、中性粒细胞比例(NEUT)、伤口感染、最高及平均体温、热病率比较差异无显著性(P>0.05)。观察组抗菌药物平均使用时间和用药费用、高胆红素血症发生率、平均住院日明显低于对照组(P<0.05)。结论剖宫产围手术期合理应用抗菌药物,可缩短抗菌药物的使用时间,有效预防感染,降低新生儿高胆红素血症发生率及抗菌药物使用费用。
Objective To investigate the influence of perioperative antibiotics use in cesarean section on neonatal hyperbilirubinemia. Methods 253 parturients of cesarean section were selected as the research subjects and divided into 2 groups according to the differ- ent antibiotic medications. The control group（n=130） was postoperatively given only cefazolin 2.0 g adding to 0.9% sodium chloride 250 mL by intravenous drip, twice daily for continuous 3 d, while the observation group（n= 123） was given cefazolin 1.0 g adding to 0.9% sodium chloride 100 mL by intravenous drip as the preoperative prophylactic use and postoperatively given the same dose of ce- fazolin by intravenous drip, with a interval of 8h for 3 times. The occurrence rate of hyperbilirubinemia, fever and economic differences were compared between the two groups. Results The white blood cell count （WBC）, neutrophils proportion（NEUT）, wound infection, maximum and average body temperature and fever rate had no significant differences between the two groups（ P〉0. 05）. The antibiotics use time, average antibiotic costs, hyperbilirubinemia occurrence rate and average hospitalization time in the observation group were sig- nificantly lower than those in the control group with statistical differences（ P 〈 0.05）. Conclusion The perioperative reasonable antibi- otics use in cesarean section can reduce the use time of antibiotics, effectively prevent infections, reduce the occurrence rate of neonatal hyperbilirubinemia and antibiotic use expense.
出处
《中国药业》
CAS
2015年第3期52-54,共3页
China Pharmaceuticals
关键词
抗菌药物
剖宫产
新生儿
高胆红素血症
围产儿
antibiotics
cesarean section
newborn
hyperbilirubinemia
perinatal newborns
