摘要
目的:探讨不同剂量对冠心病高龄患者血管内皮功能、血脂的影响。方法:选取我院2011年6月至2014年6月收治的100例高龄冠心病患者作为研究对象,根据入院先后随机分为10mg组(33例)、20mg组(33例)和对照组(34例),分别比较三组患者治疗前后血管内皮功能、血脂的变化,并于治疗结束后对其临床疗效和安全性进行比较分析。结果:1三组患者治疗后其TC、LDL-C水平均较治疗前明显降低(P<0.05),而TG、HDL-C则并无明显改变,且组间比较各血脂指标均无明显差异(P>0.05)。2三组患者治疗后EDD、EID均较治疗前明显升高(P<0.05)。其中10mg组患者治疗后EDD、EID相比对照组明显升高,而20mg组仅EDD高于对照组,差异均具有统计学意义(P<0.05)。310mg组出现胃肠反应、肌肉疼痛以及转氨酶升高的患者虽较20mg组有所减少,但差异并不具有统计学意义(P>0.05)。结论:辛伐他汀能有效降低高龄冠心病患者血脂水平,并改善其血管内皮功能,10mg^20mg剂量范围内均具有较佳的临床疗效及安全性,建议高龄患者以10mg剂量为主,根据病情变化酌情加量,以尽可能的避免不良反应的发生。
Objective：To study the effect of different doses of simvastatin for endothelial function and blood lipids in elderly patients with coronary heart disease. Method： Selected 100 cases of elderly patients with coronary heart disease treated in our hospital from June 2011 to June 2014 as the research objects, ac-cording to the admission time randomly divided into 10mg group （ 33 cases） , 20mg group （ 33 cases） and control group （34 cases）, three groups were compared the vascular endothelial function, the change of blood lipids before and after treatment, and the clinical efficacy and safety after the treatment. Results：①The lev-el of TC and LDL-C after treatment of patients in three groups were significantly lower than that before （ P 〈0.05） , while the levels of TG and HDL-C were no obvious changes, and comparison among groups of the index of blood fat had no obvious difference（P 〈 0.05）. ②The ED and EID after treatment of patients in three groups were significantly increased than that before （ P 〈0.05） . Including that the EDD and EID of the patients in 10mg group after treatment were significantly higher than that of patients in control group, and the patients in 20mg group only with EDD higher than the control group, the differences were statistically signifi-cant （ P 〈 0.05） . ③Although the number of patients in 10mg group with gastrointestinal reaction, muscle pain and increased transaminase was decreased than that of patients in 20mg group, but the difference was not statistically significant （P 〈 0.05）.Conclusion： The simvastatin can effectively reduce the blood lipid level and improve the endothelial function of elderly patients with coronary heart disease, and the dose range of 10mg to 20mg has better clinical efficacy and safety, It suggests that elderly patients should priority to give 10mg, according to the condition changes add quantity as appropriate to avoid the occurrence of adverse re-actions.
出处
《河北医学》
CAS
2015年第2期335-339,共5页
Hebei Medicine
基金
2012年广东省医学科研基金
(编号:A2012810)
关键词
冠心病
高龄
辛伐他汀
Coronary heart disease
Old age
Simvastatin
