摘要
目的:比较不同剂量布地奈德混悬液雾化吸入辅助治疗毛细支气管炎的临床疗效和安全性。方法:选择符合标准的患儿90例,随机分为A组、B组和C组各30例,A组雾化吸入布地奈德混悬液1.0mg/次,每日3次;B组0.5mg/次,每日3次;C组1.0mg/次,每日3次,缓解后改为0.5mg/次,每日2次;疗程均为7d,观察记录两组患儿临床症状及体征的变化。结果:A组及C组患儿发热、喘憋、气促、咳嗽、哮鸣音及湿啰音消失比较,差异均无统计学意义(P>0.05),但是A组及C组患儿症状及体征消失时间均快于B组,差异有统计学意义(P<0.05)。治疗7d后,A组及C组患儿临床总有效率相似,差异均无统计学意义(P>0.05),但是均高于B组,差异有统计学意义(P<0.05)。A组患儿1例出现嗜睡、1例出现声音嘶哑,B组和C组患儿均未发生不良反应。结论:毛细支气管炎急性期采用大剂量布地奈德混悬液雾化吸入能快速缓解患者的临床症状及体征,病情缓解后减少剂量,不影响临床治疗效果,可降低不良反应,提高用药安全性。
Objective：To compare the safety and clinical efficacy of spray inhalations of different doses of budesonide suspensions in adjunctive treatment of bronchiolitis. Method：90 eligible patients were select-ed and randomly divided into group A, B, and C, with 30 patients in each group. The group A received spray inhalation of budesonide suspension, 1. 0mg 3 times daily; the group B received spray inhalation of budesonide suspension, 0.5mg 3 times daily; and the group C received spray inhalation of budesonide sus-pension, 1.0mg 3 times daily initially, and after symptomatic relief, 0.5mg twice daily;each course of treat-ment was 7 days. And the changes in the clinical symptoms and physical signs in the patients of the three groups were observed and recorded. Result：The differences in times for disappearances of fever, dyspnea, short breath, cough, wheezing sound, and moist rales in the patients between the group A and the group C were all statistically insignificant （ P〉0.05） , but the times for disappearances of the symptoms and physical signs in the patients of the group A and the group C were both less than those in the patients of the group B, and the differences were statistically significant （ P〈0.05） . After 7-day treatment, the patients of the group A and the group C had similar clinical total response rates, and the difference was statistically insignificant （ P〉0.05） , but the patients of both groups had higher clinical total response rates than the patients of the group B, and the differences were statistically significant （P〈0.05）. One patient of the group A suffered from drowsiness, and another patient of the group suffered from hoarse voice, but no patient in the group B or the group C suffered from any adverse reactions.Conclusion：Use of spray inhalation of a large dose of budes-onide suspension in the acute stage of bronchiolitis can rapidly relieve the clinical symptoms and physical signs in the patients, and a dose reduction after symptomatic relief can reduce the incid
出处
《河北医学》
CAS
2015年第2期225-228,共4页
Hebei Medicine
基金
四川省科技厅资助项目
(编号:2013SZ0127)
