摘要
高密度脂蛋白(HDL)通过胆固醇逆向转运、抗氧化、抗炎、抗血栓形成、保护血管内皮细胞等功能发挥其抗动脉粥样硬化(As)作用。近年来研究发现HDL含量与其功能不成比例,在As、代谢综合征、慢性炎症、免疫系统疾病患者体内,HDL组分改变如蛋白成分氧化、糖基化等修饰可降低其抗As功能,甚至表现出促炎、促氧化等特性,成为As发生发展的危险因素。
High density lipoprotein（ HDL） exhibits antiatherogenic properties for its functions in reverse cholesterol transport,antioxidant,anti-inflammation,anti-thrombosis and protection of vascular endothlial cells. Accumulating evidence has revealed that HDL levels are not positively related with their functions in the patients with atherosclerosis,metabolic syndrome,chronic inflammation or immune system disease. HDL,especially its protein composition,is susceptible to chemical modification including oxidation or glycation and may lose its beneficial role against atherosclerosis,even exhibit pro-atherogenic effect,such as proinflammatory and prooxidation.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第10期1067-1071,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81370381
81202949)
山东省泰山学者岗专项基金(zd056
zd057)
关键词
高密度脂蛋白
蛋白成分修饰
动脉粥样硬化
功能改变
High Density Lipoprotein
Protein Modification
Atherosclerosis
Functional Changes
