摘要
目的评价心内科住院患者肱踝脉搏波传导速度（baPWV）与左心室舒张功能的关系。方法选择652例于2012年11月至2013年10月因心血管疾病在北京大学第一医院心内科住院患者,收集一般住院资料,测定baPWV,行心脏彩超等检查。以左心室舒张功能不同分为舒张功能正常组（E/A≥0.8,E/E’≤8）、轻度舒张功能不全组（E/A〈0.8,E/E’≤8）、中度舒张功能不全组（0.8≤E/A≤1.5,8〈E/E’〈13）、重度舒张功能不全组（E/A≥2.0,E/E’≥13）,比较四组间baPWV水平。采用Spearman相关分析判定baPWV与左心室舒张功能的相关性。以重度左心室舒张功能不全（E/E’≥13）作为终点事件,应用多因素Logistic回归模型校正影响左心室舒张功能不全的混杂因素。结果四组间baPWV随左心室舒张功能减退而升高（P〈0.001）。研究对象中baPWV与E/A比值呈明显负相关（r=-0.257,P〈0.001）,baPWV与E/E’比值呈明显正相关（r=0.249,P〈0.001）。多因素Logistic回归分析显示,baPWV≥1400 cm/s是左心室舒张功能不全的危险因素,其RR值为1.93（95%CI为1.09~3.44,P=0.03）。结论 baPWV与左心室舒张功能具有相关性,可以作为左心室舒张功能减退的高危人群的筛查方法。
Aim To assess the relationship between brachial-ankle pulse wave velocity（baPWV） and left ventricular diastolic function of hospitalized patients in department of cardiology. Methods 652 patients in department of cardiology were enrolled in the study. The informations of clinical and ultrasonic cardiography were collected. Brachialankle pulse wave velocity was measured noninvasively. Results BaPWV increased with the decline of left ventricular diastolic function in four groups and there was statistical significance（ P 〈 0. 001）. BaPWV was significantly negatively correlated with E /A ratio（ r =-0. 257,P 〈 0. 001）,and was significantly positively correlated with E /E’ ratio（ r =0. 249,P 〈 0. 001）. Multiple Logistic regression analysis showed baPWV≥1400 cm /s was a danger factor to left ventricular diastolic disfunction,the RR values were 1. 93（95% CI was 1. 09 ~ 3. 44,P = 0. 03）. Conclusions BaPWV is correlated with left ventricular diastolic disfunction,and it can be a screening method for high risk group with left ventricular diastolic disfunction.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第9期949-953,共5页
Chinese Journal of Arteriosclerosis
关键词
肱踝脉搏波传导速度
左心室舒张功能
相关分析
Brachial-ankle Pulse Wave Velocity
Left Ventricular Diastolic Function
Correlation Analysis
