摘要
目的:探讨胃苏颗粒联合西医常规用药治疗老年胃食管反流病(gastroesophageal reflux disease,GERD)的临床效果.方法:按照随机数字表法将贵州省六盘水市水矿集团总医院收治的84例老年GERD患者均分为实验组和对照组,对照组患者给予西医常规方案治疗,实验组患者在此基础上加用胃苏颗粒治疗,比较两组患者治疗前后症状总评分和内镜评分变化情况以及疗程结束时症状疗效和内镜疗效.结果:两组患者治疗后症状总评分和内镜评分均显著下降,与治疗前比较(7.47分±2.51分vs 18.96分±2.88分,11.49分±2.35分vs19.72分±2.79分,1.49分±0.61分v s 2.49分±0.62分,1.64分±0.63分vs 2.47分±0.69分),差异具有统计学意义(P<0.05);实验组患者治疗后症状总评分和内镜评分均显著低于对照组(7.47分±2.51分vs 1.49分±0.61分,11.49分±2.35分vs 1.64分±0.63分),差异具有统计学意义(P<0.05);实验组患者症状疗效显著优于对照组(95.24%vs 80.95%),差异具有统计学意义(P<0.05);两组患者内镜疗效比较(78.57%vs 71.43%),差异无统计学意义(P>0.05).结论:在西医常规用药基础上加用胃苏颗粒可有效改善患者临床症状,提高治疗效果,可作为治疗老年GERD的优选方案.
AIM： To explore the clinical effects of Weisu granules combined with conventional Western medicines in the treatment of gastroesophageal reflux disease （GERD）.
METHODS： Eighty-four patients with GERD were randomly divided into either an experiment group or a control group. Both the control and experiment groups were treated with conventional Western medicines, and the experiment group was additionally treated with Weisu granules. Symptom score, endoscopic score, and clinical effects were compared for the two groups.
RESULTS： Symptom score and endoscopic score were significantly lower post treatment than prior treatment in both groups （7.47 ± 2.51 vs 18.96 ± 2.88, 11.49 ± 2.35 vs 19.72 ± 2.79, 1.49 ± 0.61 vs 2.49 ± 0.62, 1.64 ± 0.63 vs 2.47 ± 0.69; P 〈 0.05）. Symptom score and endoscopic score post treatment were significantly lower in the experiment group than in the control group （7.47 ± 2.51 vs 1.49 ± 0.61, 11.49 ± 2.35 vs 1.64 ± 0.63, P 〈 0.05）. The clinical effects with regard to symptom improvement were better in the experiment group than in the control group （95.24% vs 80.95%, P 〈 0.05）; there was no significant difference in clinical effects with regard to endoscopic improvement （78.57% vs 71.43%, P 〉 0.05）.
CONCLUSION： Weisu granules combined with conventional Western medicines in GERD can improve clinical symptoms and clinical effects, and can be a treatment of choice for elderly patients with GERD.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第35期5492-5495,共4页
World Chinese Journal of Digestology
关键词
胃苏颗粒
西医常规用药
老年患者
胃食管反流病
Weisu granules
Conventional Western medicine
Elderly patients
Gastroesophageal reflux disease
