摘要
脑卒中与他汀类药物的关系已经在近几年的流行病学研究中被确认,并逐渐引起临床医生的重视。有研究发现在脑卒中治疗中,早期或大剂量使用他汀类药物能显著获益,这除了他汀类药物有效的降脂效果外,其多效性效应起到了重要作用,对认清脑卒中和他汀类药物之间关系非常必要。尽管有报道称他汀类药物有可能会增加颅内出血风险,又或者存在肌病及转氨酶升高等不良反应,但他汀类药物还是安全的,且对于缺血性脑卒中患者而言,服用他汀类药物带来的获益更明显。现就近年有关脑卒中与他汀类药物之间的相关性研究进展做一综述。
The association between stroke and statins has been currently confirmed from the epidemiologic studies, and has been paid more attention by clinicians. Patients in the treatment of the stroke can obtain beneift signiifcantly from using statins in the early stage with high dosage, due to their effective lipid-lowering effect and pleiotropic effects. It is necessary to identify the association between stroke and statins. Although there were reports that statins may increase the risk of intracranial hemorrhage, and in spite of its adverse reactions, such as myopathy and transaminase eleations, statins are still safe and the patients with ischemic stroke can get the beneifts from statins obviously.
出处
《中国临床神经科学》
2014年第6期680-685,共6页
Chinese Journal of Clinical Neurosciences
