摘要
目的探讨丁苯酞软胶囊对缺血性脑卒中恢复期患者认知功能的改善作用。方法选择缺血性脑卒中恢复期患者86例,随机分为观察组和对照组。两组患者均酌情予以降压、降糖及调脂、抗血小板聚集和改善脑循环等基础治疗。观察组患者加用丁苯酞软胶囊0.2 g/次,3次/d;对照组患者加用脑复康片1.2 g/次,3次/d,两组均连用14 d。观察两组患者治疗前和治疗14 d后认知功能指标的变化,并进行疗效及安全性评估。结果治疗14 d后,两组患者WMS评分和MOCA评分均明显上升(P<0.05或P<0.01),且观察组比对照组上升更明显(P<0.05);同时观察组患者的认知功能总改善率为95.35%,明显高于对照组的79.07%(χ2=5.11,P<0.05);两组治疗中共发生药物不良反应8例,其中观察组3例,对照组5例,症状均较轻。两组不良反应比较差异无统计学意义(χ2=0.14,P>0.05)。结论丁苯酞软胶囊对缺血性脑卒中恢复期患者认知功能下降具有良好的改善作用,可促进患者认知功能的恢复,安全性较好。
Objective To discuss improvement effect of butylphthalide soft capsules on cognitive function of patients with cerebral arterial thrombosis in recovery period. Methods A total of 86 cases of patients with cerebral arterial thrombosis in recovery period were divided into observation group and control group at random. The patients in two groups were given the basic medical treatment such like depressurization, glucose-lowering, lipid-regulating, anti-platelet aggregation, cerebral circulation improvement and etc. The patients in observation group were additionally given butylphthalide soft capsules, 0.2 g per time, three times a day, while the patients in control group were additionally given piracetam tablets, 1.2 g per time, three times a day for 14 days. The changes of cognitive function indexes of pa-tients in two groups before and 14 days after the medical treatment were observed, and the curative effect and security evaluation were carried on as well. Results After 14 days’ medical treatment, WMS and MOCA scores of patients in two groups were obviously rose （P〈0.05 or P〈0.01）, and the rising rate of patients in observation group was much high-er than that in control group （P〈0.05）. Meanwhile, total improvement rate of cognitive function of patients in observa-tion group was 95.35%, much higher than that in control group （79.07%） （χ2=5.11, P〈0.05）. 8 cases of drug adverse re-action （DAR） of patients in two groups were appeared during the medical treatment, 3 cases in observation group and 5 cases in control group, with light symptom. After comparing the untoward effect of patients in two groups, no statistical differences were appeared （χ2=0.14, P＆gt;0.05）. Conclusion Butylphthalide soft capsules has favorable improvement effect on the declining of cognitive function of patients with cerebral arterial thrombosis in recovery period, which can en-hance the recovery of cognitive function of patients with favorable security.
出处
《中国现代医生》
2015年第3期101-103,共3页
China Modern Doctor
基金
浙江省医学会临床科研基金项目(2011ZYC-B9)
关键词
缺血性脑卒中恢复期
丁苯酞
认知功能
Cerebral arterial thrombosis in recovery period
Butylphthalide
Cognitive function
