摘要
目的观察CD64指数在初次人工关节置换术中的变化规律,对比CRP、ESR及IL-6的变化规律,探讨其在诊断人工关节置换术后早期感染中的意义。方法接受初次人工关节置换的患者61例,分别在术前、术后1、3、5、7天对患者的CD64指数、CRP、ESR及IL-6进行检测分析。结果测量数据结果提示所有患者的CD64指数、CRP、ESR及IL-6水平均呈先升高后下降的趋势,其中CD64指数术后3天达到高峰,其后开始明显下降,至术后第5天下降到正常范围,术后1、2、3天的CD64指数测定较术前差异均有统计学意义(t1=3.60,t2=4.53,t3=9.64,P<0.05),术后5、7天差异均无统计学意义(t5=1.77,t7=0.49,P>0.05)。CRP及ESR在术后3天达到高峰,但在术后7天均未下降到正常。而IL-6在术后第1天达到最高峰,在术后第5天下降至正常。结论 CD64指数在初次人工关节置换术后有一定的变化规律,先迅速升高3天内可达高峰,然后快速下降,5天内基本恢复正常。这种变化可以为人工关节置换术后早期感染的诊断提供参考。
Objective To study the changes of neutrophil CD64 index before and after on-set total joint arthroplasty,to compare with the changes of CRP,ESR and IL-6 and describe the differences of these three markers,and to investigate the value in diagnosing early infection after total joint arthroplasty.Methods Totally 61 patients who received on-set total joint arthroplasty between January 2013 and June 2013 in our hospital were studied.Data of CD64 index,CRP,ESR and IL-6 before surgery,at day1,day2,day3,day5 and day7 after total joint arthroplasty were tested.Results The levels of CD64 index,CRP,ESR and IL-6 all increased at first and then decreased.The level of CD64 index arrived at a peak point on the third day postoperatively,then fell down and back to normal range on the 5th day postoperatively.The levels of CD64 index at day1,day2,day3 after total joint arthroplasty were higher than that before surgery （t1 d =3.60,t2d =4.53 t3d =9.64,P ＜ 0.05）.There was no significant difference between the level of CD64 index at day5 or day7 before and after surgery（t5d =1.77,t7d =0.49,P ＞ 0.05）.The levels of CRP and ESR elevated to a peak point on the third day postoperatively,then fell down but not return to normal range by the 7th day postoperatively.The level of IL-6 elevated to a peak point on the first day postoperatively,then fell down and back to normal range on the 5th day postoperatively.Conclusion The range of neutrophil CD64 level can increase to peak point in early post-operative 3 days after onset total joint arthroplasty,then it is followed by a rapid return to nearly preoperative levels by day 5.We can expect this data to provide favors for early diagnosis of postoperative periprosthetic infection.
出处
《医学研究杂志》
2014年第12期105-108,共4页
Journal of Medical Research
