摘要
目的：评估老年患者的万古霉素血药浓度、临床疗效及肾毒性。方法回顾性分析我院呼吸科用万古霉素并监测血药浓度的39例老年患者的临床资料。结果万古霉素的治疗有效率为82.05％；谷浓度在10～20 mg · L－1占48.12％，谷浓度＜10 mg · L－1的19例患者中有6例进行了剂量调整，2例（5.13％）患者出现了肾毒性，万古霉素减量或停用后肌酸酐均恢复至基础水平。3例（7.69％）用药前肾功能不全的患者均未有肾毒性发生。万古霉素联用依替米星及利尿剂未发生肾毒性。结论老年患者用万古霉素时应调整剂量，并借助血药浓度的监测对万古霉素进行调整。
Objective To evaluate the drug plasma concentration , clini-cal efficacy and renal toxicity of vancomycin .Methods The clinical da-ta （ basic disease , bacteriological results , the serum concentrations of vancomycin , clinical efficacy , renal toxicity and initial dose selection ） of 39 elder patients were retrospectively analyzed.Results The effective rate of vancomycin was 82.05%.Vancomycin trough concentration be-tween 10-20 mg · L-1 accounted for 48.12%.Among the 19 patients whose vancomycin trough concentrations were less than 10 mg · L-1 , 6 cases adjusted the dose , 2 cases （ 5.13%） had renal toxicity , but the creatinine returned to basal levels after vancomycin was reduced or stopped.Renal toxicity didn′t appear in 3 cases （7.69%） who had renal insufficiency before using vancomycin.When vancomycin was combined with etimicin and diuretics , renal toxicity didn′t appear.Conclusion The dose of vancomycin should be adjusted in elder pa-tients.We should monitor serum concentration of vancomycin to adjust its legitimately use.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第2期127-129,共3页
The Chinese Journal of Clinical Pharmacology
关键词
老年
万古霉素
血药浓度监测
肾毒性
elderly vancomycin serum drug monitoring renal toxicity
