摘要
目的：探讨新疆地区HBV基因分型构成特点及其与肝硬化之间的关系。方法收集2011年10月至2013年6月新疆维吾尔自治区中医医院收治的慢性HBV感染者1018例。其中检测出基因型、资料完整的828例。根据实验室检查及彩超或CT结果将患者分为慢性乙型肝炎组、肝硬化组、原发性肝癌组。采用PCR法对HBV基因分型，运用列联卡方、秩和检验、多因素Logistic回归分析等方法对HBV基因型与临床病情及相关慢性肝病结局进行分析。结果828例患者中，以C型为主，占总样本的54．11％（448／828），B型占25．15％（200／828），D型占16．18％（134／828）；各基因型病情程度构成差异无统计学意义（H＝0．1689，P＞0.05）；116例肝硬化患者中基因C型占20．84％，与B型和D型相比较差异均有统计学意义（χ2值分别为25．486、20．947，P值均为0．000）；乙型肝炎病程10年以上、基因C型、HBV DNA高病毒载量、ALT＞ULN进入回归模型（P＜0．05）。其中基因C型与肝硬化的相关度最高（OR＝2．819，95％CI：1．582～5．021）。结论新疆地区HBV基因分型以C型为主，其次为B型、D型。基因C型是HBV相关肝硬化患者的独立危险因素。
Objective To investigate the distribution of hepatitis B virus （HBV）genotypes among patients in Xinjiang Uygur Autonomous Region,China,and to explore its association with liver cirrhosis.Methods HBV genotypes of 1018 hepatitis B patients were determined by PCR analysis.The relationship of HBV genotype with clinical outcomes and relevant chronic liver diseases was assessed by contingency chi-square test,Kruskal-Wallis test,and multivariate unconditional logistic regression analysis.Results Among the 828 patients whose HBV genotyping was completed in this study,type C was the major genotype and the percentage was 54.11%（448/828）,25.15%（200/828） had type B,and 16.18%（134/828）had type D.Among the 116 patients with liver cirrhosis,20.84%had type C,which was significantly more frequent than other genotypes （P＆lt;0.00）.The multivariate unconditional logistic regression model identified several risk factors for liver cirrhosis,including duration of hepatitis B≥10 years,C genotype,high HBV DNA viral load,and impaired liver function character-ized by abnormal alanine aminotransferase test.Among all these factors,genotype C had the highest relevance to liver cirrhosis （OR=2.819,95% CI：1.582-5.021）.Conclusion The leading genotype of HBV in Xinjiang Uygur Autonomous Region is type C,followed by type B and type D.Genotype C is an independent risk factor for HBV-related liver cirrhosis.
出处
《临床肝胆病杂志》
CAS
2014年第12期1307-1309,共3页
Journal of Clinical Hepatology
基金
新疆维吾尔自治区自然科学基金项目(20123314619)
关键词
肝炎
乙型
慢性
基因型
肝硬化
hepatitis B,chronic
genotype
liver cirrhosis
