摘要
目的 系统评价5-氨基酮戊酸光动力疗法（ALA-PDT）治疗尖锐湿疣的临床疗效及安全性.方法 计算机检索Cochorane Library、PubMed、EMBASE、CNKI、CBM、VIP等数据库,检索的日期从1990年至2012年5月.收集所有5-氨基酮戊酸光动力疗法治疗尖锐湿疣的临床随机对照试验（RCT）,并对其进行系统评价,治疗组为ALA-PDT组,对照组为CO2激光组.结果 最终3个随机对照试验完全符合本系统评价的纳入标准,纳入患者是597例,Meta分析显示ALA-PDT治疗尖锐湿疣治愈率高,为90.0％,对照组为71.0％,其差异有统计学意义（RR=1.27,95％CI为1.15～1.42,P＜0.000 01）.局部不良反应,治疗组8.4％,对照组66.5％,其差异有统计学意义（RR=0.13,95％CI为0.10～0.18,P＜0.000 01）.结论 ALA-PDT治疗尖锐湿疣治愈率高,局部不良反应轻微,患者依从性较好,是一种安全有效的治疗方法.
Objective To assess the efficacy and safety of topical 5-aminolevulinic acid photodynamic therapy （ALA-PDT） in curing genital warts. Methods Cochorane Library （1990-2012）, PubMed （1990-2012）, EMBASE （1990-2012）, Chinese Biomedical Literature Database （CBM） （1990-2012）, China National Knowledge Infrastructure （CNKI） （1990-2012）, VIP database （1990-2012）, as well as reference lists of relevant studies were searched. Two reviewers independently screened searched studies, extracted data and evaluated their ethodological qualities. RevMan 5.1.0 software was used for meta-analysis. Results Three RCTs involving 597 people were included. Among them, three studies demonstrated the complete response rate of locally-used photodynamic therapy as compared to CO2 laser for treating genital warts. Based on meta-analysis, the rate of complete response of the two interventions differed significantly （ALA-PDT： 90.0%; CO2 laser. 71.0%）. Three had statistical significant difference between the two groups （RR=l.27, 95%CI：1.15-1.42, P 〈0.000 01）. Local reactions, treatment group was 8.4% ,66.5%in the control group. There was statistically significant difference （RR =0.13, 95% CI：0.10-0.18, P〈0.000 01）. Conclusion ALA-PDT tends to be a fairly well-tolerated form of therapy. According to different routes of administration, ALA- PDT appears to be much more effective than CO2 laser for treating genital warts in either improving the complete response rate or reducing the side-effect rate for the treatment of genital warts.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2014年第6期368-371,共4页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
氨基酮戊酸
光化学疗法
尖锐湿疣
随机对照试验
Meta分析
5-aminolevulinic acid photodynamic
Photochemotherapy
Condyloma acuminatum
Randomized controlled trial
Meta-analysis
