摘要
目的探讨血清炎性细胞因子白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)与进展性脑梗死发生发展的相关性。方法采用ELISA方法检测97例急性脑梗死患者(其中进展性脑梗死组37例,非进展性脑梗死组60例)入院后1 d、3 d、5 d、7 d的血清炎性细胞因子IL-6及TNF-α水平和50例正常对照者的IL-6及TNF-α水平,并进行比较。结果进展性脑梗死组各时间点IL-6及TNF-α的浓度均明显高于无进展性脑梗死组及正常对照组(均P<0.05)。无进展性脑梗死组各时间点IL-6及TNF-α浓度亦明显高于正常对照组(均P<0.05)。结论进展性脑梗死发生发展过程中患者血清炎性细胞因子IL-6及TNF-α水平明显升高,可作为进展性脑梗死的重要血清蛋白标志。
Objective To investigate the relationship of the progressive cerebral infarction and the serum levels of inflammatory cytokine interleukin-6 （IL-6） and tumor necrosis factor-a （TNF-a）. Methods Serum inflammatory cytokines IL-6 and TNF-a were detected using ELISA in 97 acute cerebral infarction patients （37 patients with progressive cerebral infarction, and 60 patients with non progressive cerebral infarction） on ld, 3d, 5d, 7d after admission and in 50 normal controls, the results were compared. Results IL-6 and TNF-a in each time point of progressive cerebral infarction group were significantly higher than those in non progressive cerebral infarction group and normal control group（ all P 〈 0.05 ）. IL-6 and TNF-a in each time point of non progressive cerebral infarction group were also significantly higher than those in normal control group （ all P 〈 0. 05）. Conclusion Serum levels of inflammatory cytokines IL-6 and TNF- a increase significantly in the development of progressive cerebral infarction and can be used as an important marker of progressive cerebral infarction.
出处
《临床神经病学杂志》
CAS
北大核心
2014年第6期455-457,共3页
Journal of Clinical Neurology
基金
海南省自然科学基金(812174)
