摘要
目的体脂量和肥胖相关（fat mass and obesity associated,FTO）基因与体质指数增加以及过多能量摄入相关。文中探讨FTO基因多态性与环境因素的交互作用对哈萨克族学龄儿童肥胖的影响。方法从＂伊犁哈萨克自治州哈萨克族学龄儿童超重肥胖调查＂中选择279名6~13岁小学生,根据中国肥胖问题工作组提出的《中国学龄儿童青少年超重、肥胖筛查体质指数值分类标准》中不同年龄、性别的BMI判定,分为肥胖组（141名）和正常组（138名）,进行体格检查、问卷调查以及FTO基因rs9939609多态性检测。结果采用主成分方法进行探索性因子分析,共提取不良饮食习惯、食欲状况、户外活动、挑食情况、活动方式和睡眠时间6个因子。Logistic回归分析显示,FTO基因rs9939609与食欲状况、户外活动的交互作用归因百分依次为76.49%、79.95%。结论在哈萨克族学龄儿童中,食欲状况、户外活动可能修饰FTO基因与肥胖的关系,但需要进一步前瞻性的干预性研究证实该种影响作用。
Objective The fat mass- and obesity-associated （FTO） gene is related to increased body mass index （BMI） and elevated energy intake. This study explored the contribution of the interaction between FTO gene polymorphism and life style to the risk of obesity in the Kazakh schoolchildren. Methods A total of 279 Kazakh schoolchildren aged 6 - 13 years were selected from Yili Kazakh Child Obesity Study and divided into an obesity group （n = 141 ） and a normal weight group （n = 138） based on the BMI cutoffs recommended by the Chinese Working Group on Obesity for Children. The children were subjected to anthropometric measurement, questionnaire investigation, and determination of the rs9939609 polymorphism of the FTO gene. Results Six risk factors of obesity were extracted by factor analysis, including harmful eating habits, appetite status, outdoor activities, fussiness about food, activity mode, and hours of sleep. Logistic regression analysis showed that the interaction between rs9939609 polymorphism and appetite status constituted an obesity risk of 76.49%, and that between rs9939609 polymorphism and outdoor activities constituted an obesity risk of 79.95%.Conclusion Appetite status and outdoor activities might modify the relationship of the FTO gene with the risk of obesity in Kazakh schoolchildren. However, further prospective interventions are needed verify the influence of the interaction between the FTO gene and life style on the risk of obesity.
出处
《医学研究生学报》
CAS
北大核心
2014年第12期1281-1285,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81060072)
