摘要
目的:研究阿托伐他汀联合苯磺酸氨氯地平治疗冠心病合并脑梗死的临床效果。方法:从2011年1月到2013年1月,在我院共有96例病患被诊断为冠心病合并脑梗死。以数字法随机分成观察组(48例)和对照组(48例)。对照组每天口服苯磺酸氨氯地平,观察组在对照组的基础上口服阿托伐他汀钙片。对比两组疗效及病患血脂水平。结果:观察组疗效为优者占比62.50%(30/48),优良率为91.67%(44/48),均显著高于对照组的39.58%(19/48),75.00%(36/48),差异均有统计学意义(均P<0.05);观察组治疗后TC(4.74±1.20)mmol/L,显著性低于对照组(5.22±1.15)mmol/L,TG(1.06±0.30)mmol/L,显著性低于对照组(1.51±0.28)mmol/L,LDL-C(3.19±0.51)mmol/L,显著性低于对照组(3.87±0.25)mmol/L,上述差异均有统计学意义(P<0.05)。结论:阿托伐他汀联合苯磺酸氨氯地平治疗冠心病合并脑梗死,不仅可明显提升治疗效果,还可减少病患的并发症的发生。方便安全,值得临床推荐。
Objective： To study the therapeutic effect of combined atorvastatin amlodipine besylate in treatment of coronary heart disease and cerebral infarction. Methods： 96 patients in our hospital who were diagnosed coronary heart disease and cerebral infarction from January 2011 to January 2013 were selected and were digitally randomly divided into observation group（48 cases） and control group（48 cases）. The control group was treated with amlodipine besylate daily, and the observation group was treated with atorvastatin calcium on the basis of the control group. The therapeutic effect and the blood lipid levels of two groups of patients was compared.Results： The patients of the observation group were excellent accounting for 62.50%（30/48）, good for 91.67%（44/48）, which were significantly higher than that of control group, which were 39.58%（19/48）,75.00%（36/48）, respectively. The differences was statistically significant（P〈0.05）. TC in observation group was（4.74±1.20） mmol/L, which was significantly lower than that of control group（5.22±1.15） mmol/L, and TG was（1.06±0.30） mmol/L, LDL-C was（3.19±0.51） mmol/L, which were significantly lower than control group＇s（1.51 ±0.28） mmol/L and（3.87 ±0.25） mmol/L. Differences above all showed statistically significant（P〈0.05）. Conclusions：Atorvastatin combined amlodipine in treatment of coronary heart disease and cerebral infarction can significantly improve the therapeutic effect, also can reduce the occurrence of complications in patients.
出处
《现代生物医学进展》
CAS
2014年第35期6913-6915,共3页
Progress in Modern Biomedicine
基金
教育部留学回国人员科研启动基金(教外司留(2011)1568号)
关键词
阿托伐他汀
苯磺酸氨氯地平
冠心病
脑梗死
Atorvastatin
Amlodipine Besylate Tablet
Coronary artery disease
Cerebral infarction
