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抑癌基因PTEN与纤维化疾病关系的研究进展

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摘要 第10号染色体缺失的磷酸酶和张力蛋白同源基因PTEN是一个编码具有脂质磷酸酶和蛋白磷酸酶双重特异性磷酸酶活性产物的抑癌基因.可通过PI3K-PKB/Akt、FAK途径、MAPK途径等信号通路对细胞的生长、增殖、分化、凋亡、粘附、迁移和浸润等许多生物学行为发挥作用,在恶性肿瘤和纤维化疾病中发挥重要作用.
出处 《国际泌尿系统杂志》 2015年第1期120-123,共4页 International Journal of Urology and Nephrology
基金 国家自然科学基金资助项目(编号:81360116) 贵州省社会发展科技攻关计划资助项目(No:黔科合sY字【2012】3088号)
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