摘要
目的探讨枳术丸挥发油对慢传输型便秘(slow transit constipation,STC)大鼠的治疗作用及可能的作用机理。方法应用盐酸吗啡制作STC模型大鼠,采用活性炭悬液推进法测定枳术丸挥发油干预前后STC模型大鼠肠道推进功能,并采用在体结肠肌电测定法测定枳术丸挥发油干预前后STC模型大鼠结肠的肌电活动情况。结果与模型对照组相比,枳术丸挥发油组的STC大鼠肠道推进率增加(P<0.05),结肠慢波振幅减小(P<0.05)、频率加快(P<0.05),振幅及频率变异系数均减小(P<0.05)。结论枳术丸挥发油可增强STC结肠推进功能,其治疗作用机制之一是纠正STC异常的结肠慢波。
Objective To explore the effects and mechanism of the valatile oil extracted from Zhizhu Pill on the slow transit constipation （ STC） in rats.Methods The STC rat models were established with morphine hydrochloride .The intestinal propulsion functions of STC model rats were detected by the ac-tivated carbon powder suspension propulsion method before and after the intervention of the valatile oil of Zhizhu pill.The colonic muscle electric activity of STC model rats were detected by the in vivo colon myo-electricity measurement method .Results Compared to the model control group , the intestinal propulsion function enhanced significantly after the treatment of the valatile oil of Zhizhu pill , where the amplitude , the coefficient variation of the amplitude and frequency all decreased , and the frequency increased （ all P〈0.05）.Conclusion The valatile oil of Zhizhu pill could enhance the STC and improve the colon propul-sion function, with the potential mechanism by correcting the slow waves of colon with abnormal STC .
出处
《环球中医药》
CAS
2015年第1期26-28,共3页
Global Traditional Chinese Medicine
关键词
慢传输型便秘
枳术丸挥发油
活性炭悬液推进法
在体结肠肌电测定
Slow transit constipation
Zhizhu Pill
Valatile oil
Activated carbon powder suspension propulsion method
In vivo colon myoelectricity
