期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

α_2肾上腺素受体与镜像痛调制 被引量：1

Alpha-2 adrenergic receptor and mirror-ARimage pain modulation
下载PDF
导出
摘要 镜像痛为躯体一侧组织或神经损伤时产生疼痛及痛敏,在对侧对应区域亦产生疼痛及痛敏的现象。α2肾上腺素受体(alpha-2 adrenergicreceptor,α2-AR)在痛觉调制过程中起着重要作用,在镜像痛研究显示α2-AR激动剂亦可减缓镜像痛敏。现就镜像痛的发生机制结合最新的研究进展,探讨α2-AR参与镜像痛调控的可能机制。α2-AR在镜像痛的调制方面或具重要作用。 Mirror-ARimage pain is a spontaneous pain and hyperalgesia induced by tissue or nerve injury in both the injured and the contralateral site.Alpha-2 adrenergic receptor（α2-AR） plays an important role in pain modulation,and α2-AR agonists may relief the mirror-ARimage hyperalgesia in the study of mirror-ARimage pain.This review updates possible mechanisms of α2-AR involved in the mirror-ARimage pain modulation.It is demonstrated that α2-AR may play a significant role in the mirror-ARimage pain modulation.
作者 侯仁浩 刘霞 白占涛
机构地区 延安大学生命科学学院
出处 《延安大学学报（医学科学版）》 2014年第4期67-70,共4页 Journal of Yan'an University:Medical Science Edition
基金 国家自然科学基金面上项目(81171038 81470051) 陕西省科技厅项目(2010JM404 2011K17-01-04和2012K01-12) 陕西省教育厅项目(12JS121) 陕西省高水平大学建设专项资金资助项目(2012SXTS06)
关键词 α2肾上腺素受体 激动剂 镜像痛 镇痛 Alpha-2 adrenoceptor Agonist Mirror-ARimage pain Analgesia
分类号 R971.1 [医药卫生—药品]
  • 相关文献

参考文献5

二级参考文献163

  • 1胡玉萍,杨建军,李伟彦,稽晴.胶质细胞源性神经营养因子家族在大鼠坐骨神经慢性压榨损伤中的作用[J].医学研究生学报,2011,24(12):1236-1241. 被引量：3
  • 2许学兵,姚尚龙,佘守章,许立新,董源洪.慢性神经痛大鼠脊髓缝隙连接蛋白43基因表达变化的实验研究[J].中国疼痛医学杂志,2005,11(5):294-297. 被引量：5
  • 3Kanno S, Saffitz JE. The role of myocardial gap junctions in electrical conduction and arrhythmogenesis. Cardiovasc Pathol 2001; 10: 169- 77. 被引量：1
  • 4Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 2003; 83: 1359-400. 被引量：1
  • 5Sohl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res 2004; 62: 228-32. 被引量：1
  • 6Beauchamp P, Choby C, Desplantez T, de Peyer K, Green K, Yamada KA, et al. Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res 2004; 95 170-8. 被引量：1
  • 7Gutstein DE, Morley GE, Vaidya D, Liu F, Chen FL, Stuhlmann H, et al. Heterogeneous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation 2001; 104: 1194-9. 被引量：1
  • 8BaoX, AltenbergGA, Reuss L. Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation. Am J Physiol Cell Physiol 2004; 286: C647-C654. 被引量：1
  • 9Huang XD, Sandusky GE, Zipes DP. Heterogeneous loss of connexin43 protein in ischemic dog hearts. J Cardiovasc Electrophysiol 1999; 10: 79-91. 被引量：1
  • 10Wang X, Gerdes AM. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs, III: intercalated disc remodeling. J Mol Cell Cardiol 1999; 31: 333-43. 被引量：1

共引文献33

同被引文献14

  • 1Roth B L,Willins D L, Kristiansen K, et al. 5-Hydroxytrypta mine2-family receptors (5-hydroxytryptamine2A ,5-hydroxyt ryptamine2B, 5-hydroxytryptamine2C ): where structure meets function [ J ]. Pharmacol Ther, 1998,79 ( 3 ) : 231 - 257. 被引量：1
  • 2Wang D, Zhou X and Hong Y. Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats[ J]. Eur J Pharmacol,2013,721 ( 1 - 3): 126 - 132. 被引量：1
  • 3Wei H, Chen Y and Hong Y. The contribution of peripheral 5 - hydroxytryptamine2A receptor to carrageenan - evoked hyperalgesia,inflammation and spinal Fos protein expression in the rat[ J ]. Neuroscience ,2005,132 (4) : 1073 - 182. 被引量：1
  • 4Maeshima T, Ito R, Hamada S, et al. The cellular localization of 5 - HT2A receptors in the spinal cord and spinal ganglia of the adult rat[J]. Brain Res,1998,797( 1 ) :118 - 124. 被引量：1
  • 5Van Steenwinckel J, Noghero A, Thibault K, et al. The 5 - HT2A receptor is mainly expressed in nociceptive sensory neurons in rat lumbar dorsal root ganglia[ J]. Neuroscience, 2009,161 (3) :838 - 846. 被引量：1
  • 6Gackiere F and Vinay L. Serotonergic modulation of post - synaptic inhibition and locomotor alternating pattern in the spinal cord[J]. Front Neural Circuits,2014,8:102. 被引量：1
  • 7Sasaki M, Obata H, Saito S, et al. Antinociception with in- trathecal alpha - methyl - 5 - hydroxytryptamine, a 5 - hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain [ J ]. Anesth Analg, 2003,96 (4) : 1072 - 1078,. 被引量：1
  • 8Dogrul A, Seyrek M, Yalcin B, et al. Involvement of descend- ing serotonergic and noradrenergic pathways in CB1 receptor - mediated antinociception [ J ]. Prog Neuropsychopharmacol Biol Psychiatry,2012,38 ( 1 ) :97 - 105. 被引量：1
  • 9Seyrek M, Kahraman S, Deveci MS, et al. Systemic cannabi- noids produce CB( 1 ) -mediated antinociception by activa- tion of descending serotonergic pathways that act upon spinal 5 -HT(7) and 5 - HT(2A) receptors[J]. Eur J Pharma- col,2010,649 ( 1 - 3 ) : 183 - 194. 被引量：1
  • 10Xie H, Dong ZQ, Ma F, et al. Involvement of serotonin 2A receptors in the analgesic effect of tramadol in mono - ar- thritic rats [ J ]. Brain Res, 2008,1210:76 - 83. 被引量：1

引证文献1

二级引证文献1

延安大学学报（医学科学版）
2014年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部