摘要
目的探讨感染性腹泻患儿血内皮素(ET)、D-二聚体(D-D)、纤维蛋白原(FBG)水平变化。方法感染性腹泻患儿60例,其中轻型、中型、重型各20例,健康婴幼儿20例作为对照组,检测各组血ET、D-D、FBG、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)值。结果各组间ET、D-D、FBG水平比较,差异有统计学意义(P<0.01),腹泻程度越重,ET、D-D、FBG水平越高(P<0.01);各组APTT、PT、TT水平比较,差异无统计学意义(P>0.05);腹泻患儿血ET水平与D-D水平呈正相关(P<0.01),D-D水平与FBG水平呈正相关(P<0.05)。结论重型腹泻患儿血管内皮细胞功能紊乱,凝血和纤溶系统激活。
Objective To investigate the changes of blood endothelin（ ET）,D-dimer（ D-D）,fibrinogen（ FBG） levels in children with infectious diarrhea. Methods Sixty children with infectious diarrhea were enrolled in the study,including 20 mild,20 medium and 20 severe cases. Another 20 healthy infants were adopted as control group. Blood ET,D-D,FBG,activated clotting enzyme live time（ APTT）,prothrombin time（ PT） and thrombin time（ TT） were detected in each group. Results There were significant differences in the ET,D-D and FBG levels among groups（ P〈0. 01）. The higher the severity of diarrhea was,the higher the ET,D-D and FBG levels were（ P〈0. 01）.There was no significant difference in the APTT,PT,TT levels（ P〉0. 05）. ET level positively correlated with D-D level（ P〈0. 01）,and D-D level positively correlated with FBG level in diarrhea children（ P〈0. 05）. Conclusion Dysfunction of vascular endothelium as well as the activation of blood coagulation and fibrinolysis system can be observed among severe diarrhea children.
出处
《广西医学》
CAS
2014年第12期1725-1727,共3页
Guangxi Medical Journal
基金
广西玉林市科学研究与技术开发计划项目(0866006)
