摘要
随着骨组织工程研究的迅速发展,寻求能够作为细胞移植及引导新骨生长的支架,以充当细胞外基质的替代物成为研究的主要热点之一。目前国内外学者尝试利用生物材料复合技术,通过调节复合材料的比例及相应的组合方式使其发挥各自的优点,进而制作出理想的支架材料。本文分别就丝素蛋白、壳聚糖以及丝素蛋白-壳聚糖复合生物材料的结构、性能及其在骨组织工程的应用做一综述。
With the rapid development of the bone tissue engineering, it has become the key to seek suitable scaffolds for cell transplantation and guide the growth of new bone to act as substitutes of the extracellular matrix. At present, the domestic and foreign scholars have used biological composite material technology to make ideal scaffold materials. They have tried to show respective virtues of composite materials through adjusting the ratio and corresponding combination ways. This paper reviewed fibroin and chitosan, and the structure and properties of silk fibroin-chitosan composite biomaterial and its application in bone tissue engineering.
出处
《中国实用口腔科杂志》
CAS
2014年第12期757-761,共5页
Chinese Journal of Practical Stomatology
基金
辽宁省科技计划项目(2012225082)
关键词
丝素-壳聚糖支架
骨组织工程
silk fibroin-chitosan scaffcold
bone tissue engineering
