摘要
目的探讨OPRM1基因多态性(rs1799971)对浙南地区女性妇科手术患者舒芬太尼自控镇痛效果的影响。方法收集浙南地区妇科手术患者200例,抽取外周血,采用直接测序法,分析患者OPRM1基因多态性(rs1799971),比较不同基因组患者之间舒芬太尼的累积量,记录镇痛起效时间、持续时间、VAS分值及不良反应。结果 AA型127例,AG型62例,GG型1 1例,OPRM1基因多态性(rs1799971)基因突变频率为36.50%,各基因组术后2、6、12h舒芬太尼累积量比较,AA组累积量最少,AG组及GG组均较AA组增高,差异有统计学意义(P<0.05),术后24、48h,GG组较AA组及AG组增高,差异有统计学意义(P<0.05)。各基因型组间不良反应发生率的差异均无统计学意义(均P>0.05)。结论在浙南地区女性人群中,OPRM1基因多态性(rs1799971)对舒芬太尼镇痛效果有显著影响。
Objective To investigate the association between OPRM1 gene polymorphisms and efficacy of sufen-tanil in postoperative patient- control ed analgesia . Methods Two hundred patients undergoing hystermyoma received post-operative patient- control ed analgesia （PCA） with sufentanil from January 2010 to May 2012. Peripheral blood samples were col ected for DNA extraction. OPRM1 gene（rs1799971） polymorphisms were detected. The sufentanil consumption, the release time on analgesia, analgesic duration, VAS, and adverse reaction were documented and compared among different genotype groups. Results Genotyping analysis revealed that the genotype distribution of polymorphisms in OPRM1 gene was AA in 127 cases, AG in 62 cases, and GG in 11 cases. The frequency of OPRM1 mutation was 36.5%. The sufentanil consumption at 2h, 6h and 12h after surgery and VAS at 24h and 48h after surgery in GG group were higher than those in AG and AA groups （P〈0.05）. Conclusion The results indicate that OPRM1 gene polymorphism has the significant impact on analgesic efficacy of sufentanil.
出处
《浙江医学》
CAS
2014年第24期1997-1999,共3页
Zhejiang Medical Journal
关键词
OPRM
基因多态性
舒芬太尼
自控镇痛
μ- opioid receptor gene Polymorphisms Sufentanil Postoperative analgesia
