摘要
内质网应激(ERS)是由于各种原因引起的内质网中出现错误折叠或未折叠蛋白在腔内聚集以及钙离子平衡紊乱的状态。ERS与各种肝病的发病机制密切相关,因此对ERS进行干预将对肝病的预防和治疗提供新的机会。本文介绍了ERS引起的未折叠蛋白反应及其干预药物在肝病的预防和治疗中可能提供的新的靶点。
Endoplasmic reticulum （ER） homeostasis is perturbed by various pathological conditions,and a given new syn- thesized unfolded proteins might accumulate in the ER and result in endoplasmic rcticulum stress （ERS）. ERS is related to the pathogenesis of the various liver diseases,and some scholars believe that the intervention of ERS will provide new choices for prevention and treatment of liver diseases. This paper will review the unfolded protein response due to ERS,which might be the target for medical intervention for liver diseases.
出处
《实用肝脏病杂志》
CAS
2015年第1期92-96,共5页
Journal of Practical Hepatology
关键词
内质网应激
未折叠蛋白反应
抑制剂
基因治疗
Endoplasmic retieulum stress
Unfolded protein response
Inhibitor
Gene therapy
