摘要
以季铵盐负载氯化钯为催化剂,由芳香醛、α,β-二羰基化合物、尿素(硫脲)合成了3,4-二氢嘧啶-2(1H)-酮/硫酮化合物.结果表明:该合成方法使用季铵盐负载氯化钯为催化剂,在中性条件下合成目标化合物的产率最高.催化剂Pd Cl2/BTEACl是一种用量少、均相、中性、高效、可重复使用的催化Biginelli反应的催化体系.该方法反应条件温和、操作简单、实际应用性强,催化剂经简单分离后可循环使用.HPLC测定结果证实此催化体系循环使用7次后催化活性降低不明显.
An improved one-pot procedure,which condenses an aldehyde,α,β-ketoester and urea or thiourea to yield 3,4-dihydropyrimidin-2-（ 1H）-ones / thiones,has been developed by using tetraalkylammonium-stabilized palladium chloride as the catalyst. Experimental results showed that the methodology revealed high catalytic activity for the synthesis of Biginelli reaction products. In this paper,we utilized palladium chloride-quaternary ammonium salt（ Pd Cl2/ BTEACl） as a low catalytic loading,homogeneous,neutral,efficient and reusable catalytic system for the Biginelli reaction. This approach appears to be a mild,simple,practical and reusable green process for the preparation of Biginelli products. The catalytic system can be easily separated,and reused for seven times without a considerable change in its activity detected by HPLC.
出处
《华南师范大学学报（自然科学版）》
CAS
北大核心
2015年第1期73-80,共8页
Journal of South China Normal University(Natural Science Edition)
基金
国家自然科学基金项目(5300410)
