摘要
以聚乙二醇为高分子骨架,分别通过酰氯化反应和迈克尔加成反应,将丙烯酸酯基团和多巴胺基团接到聚乙二醇端基,使得聚乙二醇丙烯酸酯-多巴胺体系既具有光聚合性能,又具有良好的粘接性能,1以及优异的生物相容性。利用FT-IR、H-NMR对其结构进行了表征。得到的聚乙二醇-多巴胺体系(PEG-Dopas)具有较好的粘接强度,放置24 h后其粘接强度会从0.90 MPa增加到1.62 MPa。PEG-Dopas的细胞贴附性好,对细胞的生物毒性较小。
In this study, a bioadhesive containing of poly（ethylene glycol） polymer skeleton, acrylate groups and dopamine groups was synthesized by using esterification and michael addition reaction. The bioadhesive has photopolymerizability,good bonding capacity and excellent biocompatibility. Its chemical structure was confirmed by RT- IR and IH-NMR. The adhesive strength ofpoly（ethylene glycol）-dopamine （PEG-Dopas） was improved from 0.90 MPa to 1.62 MPa after standing for 24 h. This kind ofbioadhesive has excellent cell attachment and low cytotoxicity.
出处
《粘接》
CAS
2015年第1期30-36,30,共7页
Adhesion
关键词
光聚合
多巴胺
生物粘合剂
photopolymerization
dopamine
bioadhesive
