摘要
抑郁症是一种严重的精神障碍,单一抗抑郁药物系统治疗后往往只有部分患者改善,有些患者的症状可能毫无缓解。尽管针对这一"难治性"抑郁症患者亚群已经发展出多种不同的治疗方法,但许多患者仍然带着慢性抑郁症状生活,生活质量和整体功能受到严重影响。一种相对较新的难治性抑郁症治疗方法就是"抗抑郁药物联合治疗"——同时用两种或两种以上的抗抑郁药物治疗。正因为抑郁症不是单一病因学的疾病,该方法可以通过同时激活不同作用机制的多种神经通路来提高治疗结果。当然同时使用多种抗抑郁药物也可能会增加不良反应的发生率及其严重程度。进一步的研究工作将是评估该难治性抑郁症治疗方法的潜在益处和风险。
Depression is a serious medical condition that is often only partially improved or completely unchanged after standard treatment with antidepressant medications. Various approaches have been developed to treat this subgroup of individuals with ＇treatment-resistant＇ depression; but many individuals continue to live with chronic depressive symptoms that seriously affect their quality of life and overall functioning. One relatively new strategy is ＇antidepressant polypharmacy＇ - simultaneously administering two or more antidepressant medications. Given the heterogeneity of the etiology of depression, this approach could improve therapeutic outcomes by concurrently activating multiple neurotogica~ pathways with different mechanisms of action, but there is also the risk that using multiple antidepressants would increase the prevalence and severity of side effects. Further work is needed to assess the potential benefits and risks of this strategy to managing treatment- resistant depression.
出处
《上海精神医学》
2014年第6期357-359,共3页
Shanghai Archives of Psychiatry
关键词
抑郁症
难治性抑郁症
抗抑郁药物
联合治疗
辅助治疗
多重机制治疗
depression
treatment-resistant depression
antidepressants
polypharmacy
adjunctive treatment
multimodal treatment
