摘要
目的利用ROC曲线探讨6种肿瘤标志物在新疆维吾尔族和汉族肺癌患者中诊断价值的差异。方法采用化学发光法检测血清中的癌胚抗原(CEA)、糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)、细胞角蛋白21-1片段(CYFRA21-1)、胃泌素释放肽前体(Pro-GRP)、鳞状细胞癌抗原(SCC)的水平,并根据ROC曲线建立合理的曲线下面积和临界值,并且比较两民族在临界值的真阳性率的差异。结果 (1)6种肿瘤标志物在汉族病例组的表达与汉族对照组的差异有统计学意义(P<0.05),维吾尔族病例组中的表达与维吾尔族对照组的差异有统计学意义(P<0.05),在汉族病例组中的表达和维吾尔族病例组差异无统计学意义(P>0.05)。(2)小细胞肺癌中Pro-GRP和NSE在汉族和维吾尔族的ROC曲线下面积均大于0.7;鳞癌中SCC、CYFRA21-1和Pro-GRP在汉族和维吾尔族的ROC曲线下面积均大于0.7;腺癌中CA125、CEA和Pro-GRP在汉族和维吾尔族的ROC曲线下面积均大于0.7。(3)小细胞肺癌中NSE在汉族和维吾尔族的临界值的真阳性率差异有统计学意义(P<0.05),临界值分别为16.31ng/mL、12.12ng/mL;鳞癌中Pro-GRP在两民族的临界值的真阳性率差异有统计学意义(P<0.05),临界值分别为20ng/L、23.03ng/L。结论 NSE和Pro-GRP临界值的真阳性率在汉族和维吾尔族中分别在小细胞癌、鳞癌中有差异,因此临床医师在诊断肺癌时,此两种指标要与民族相联系。
Objective To explore the diagnostic value differences of six kinds of tumor marker for Xinjiang Uygur and Han patients with lung cancer by using the ROC curve .Methods The chemiluminescence method was a‐dopted to detect serum CEA ,CA125 ,CYFRA21‐1 ,NSE ,Pro‐GRP and SCC levels ,and according to the receiver oper‐ating characteristic curve（ROC） the reasonable area under the curve and critical values were established ,and the differences in the true positive rate of critical values were compared between the two nationalities .Results （1） The expression of six kinds of tumor marker had statistical differences between the Han patients group and the Han con‐trol group（P〈 0 .05）;which had statistical differences between the Uygur patients group and the Uygur control group （P〈0 .05）;which had no statistical differences between the Han patients group and the Uygur patients group （P〉0 .05） .（2） The area under the ROC curve of Pro‐GRP and NSE in Han and Uygur small cell lung cancer was greater than 0 .7 ;the area under the ROC curve of SCC ,CYFRA21‐1 and Pro‐GRP in Han and Uygur squamous cell carcinoma was greater than 0 .7 ;the area under the ROC curve of CA125 ,CEA and Pro‐GRP in Han and Uygur ade‐nocarcinoma was greater than 0 .7 .（3） The difference in the true positive rate of NSE critical values in Han and Uygur small cell lung cancer had statistical significance （P〈0 .05） ,the critical values were 16 .31 ng/mL and 12 .12 ng/mL respectively ;the true positive rate of Pro‐GRP critical value in Han and Uygur squamous cell carcinoma had statistical difference（P〈0 .05） ,the critical values were 20 ng/L and 23 .03 ng/L respectively .Conclusion The true positive rate of NSE and Pro‐GRP critical values in Han and Uygur small cell carcinoma and squamous cell carcinoma has difference .Therefore in diagnosing lung cancer by clinicians ,these two kinds of indicator should be linked with the nationality .
出处
《检验医学与临床》
CAS
2015年第1期37-39,42,共4页
Laboratory Medicine and Clinic
关键词
肺癌
肿瘤标志物
不同民族
ROC曲线
lung cancer
tumor marker
different nationalities
ROC curve
