摘要
为了寻找高效、广谱的杀虫、杀菌剂,以去糖基或部分去糖基的多杀菌素为母体进行结构修饰,合成了8种大环内酯酰化衍生物,其结构经1H NMR,13C NMR和MS表征.对合成的化合物进行了生物活性测试.结果表明,这类化合物对鳞翅目、鞘翅目、双翅目、半翅目及线虫等害虫有较好的杀灭活性,其中化合物3e在100 mg/L浓度下对桃蚜的24 h杀灭率达到100%,化合物3f和3h在上药量为200μg时对假单胞菌有一定的抑制作用.
Modification of molecular structure of pesticides is a common method to seek new efficient broad-spectrum insec-ticides. This study focused on modifying the structure of deglycosylated or partially deglycosylated spinosad. Eight new mac-rolide derivatives had been synthesized by acylation. Their structures were characterized by 1H NMR, 13C NMR and MS tech-niques. Their fungicidal and insecticidal activities were also evaluated. The results showed that all compounds synthesized had excellent insecticidal activities against lepidoptera, coleoptera, diptera, hemiptera and nematoda. Compound 3e at the concen-tration of 100 mg/L presented 100%insecticidal activity against hemiptera （e.g. Myzus persicae） and compounds 3f and 3h loading 200μg presented certain inhibition against pseudomonas.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第12期2543-2550,共8页
Chinese Journal of Organic Chemistry
基金
北京理工大学基础研究基金(No.20131042006)资助项目~~
关键词
大环内酯
酰化
杀虫活性
杀菌活性
macrolide
acylate
insecticidal activity
fungicidal activity
