摘要
目的观察癌痛消外敷联合热疗治疗中重度癌性疼痛的临床疗效。方法将80例中重度癌性疼痛患者随机分为治疗组和对照组,每组40例。对照组予西医三阶梯止痛法,治疗组在对照组治疗措施基础上,加用癌痛消外敷联合热疗。两组疗程均为20天,观察镇痛效果、镇痛剂用量、卡氏评分、生活质量评分的变化情况,并评价不良反应。结果 1两组用药后镇痛起效时间比较,差异有统计学意义,治疗组较对照组起效快(P<0.05);两组用药后镇痛持续时间比较,差异无统计学意义(P>0.05)。2两组镇痛剂用量差异有统计学意义,治疗组盐酸羟考酮缓释片每日平均维持剂量较对照组小(P<0.05)。3治疗前后组内比较,两组卡氏评分差异均有统计学意义(P<0.05);组间治疗后比较,卡氏评分差异有统计学意义,治疗组较对照组提高更为明显(P<0.05)。4治疗前后组内比较,两组食欲、精神、睡眠、疲乏、日常生活5项指标差异均有统计学意义(P<0.05);组间治疗后比较,5项指标差异有统计学意义,治疗组优于对照组(P<0.05)。5治疗组共有13例患者出现不良反应,发生率为32.50%,对照组共有23例患者出现不良反应,发生率为55.00%;治疗组不良反应发生率较对照组低(P<0.05)。结论癌痛消外敷联合热疗治疗中重度癌性疼痛,起效较快,不良反应较少,可减少镇痛药的用量,从而有利于降低患者对阿片类药物的依赖性,提高患者的生活质量。
Objective This study is to observe the clinical efficacy of external application of ＂Aitongxiao＂combined with hyperthermia in releasing moderate to severe pain due to cancer. Methods Eighty patients with moderate to severe pain due to cancer were randomly divided into the treatment group and the control group,with 40 cases in each group. The control group was treated with western three-step analgesic therapy. The treatment group was treated with western threestep analgesic therapy combined with external application of＂Aitongxiao＂and thermal therapy. They were treated for twenty days. During the period,the analgesic effect,analgesic dosage,KPS-mark and life quality score were observed,and adverse effect were evaluated. Results ① Differences of analgesic onset time between the two groups have statistical significance（ P〈0. 05）,the treatment group faster than the control group. ② Differences of analgesic dosage between the two groups have statistical significance（ P〉0. 05）. The average maintenance dose of Oxycodone Hydrochloride Prolonged-release Tablets for treatment group is less than control group. ③Differences of KPS-mark within the group have statistical significance（ P〈0. 05）; differences of KPS-mark between the two groups have statistical significance（ P〈0. 05）,the treatment group more significant than the control group. ④ Differences of appetite,spirit,sleep,sleep and daily life within the group have statistical significance（ P〈0. 05）; differences of those five indexes between the two groups have statistical significance（ P〈0. 05）,the treatment group better than the control group. 5 Thirteen subjects in the treatment group had untoward effect,32. 5% of the total number. 23 subjects in the control group had untoward effect,the 55. 00% of the total number. Differences of untoward effect rate between the two groups have statistical significance（ P〈0. 05）,the treatment group lower than the control group. Conclusion There was a tendency that the patients t
出处
《上海中医药杂志》
2014年第12期44-47,共4页
Shanghai Journal of Traditional Chinese Medicine
关键词
癌性疼痛
中重度
癌痛消
外敷
热疗
生活质量
起效时间
pain due to cancer
moderate to severe
＂Aitongxiao＂
external application
thermal therapy
life quality
onset time
