摘要
目的:探讨补阳还五汤对大鼠局灶性脑缺血再灌注损伤的保护作用。方法:采用线栓法制造大鼠局灶性脑缺血再灌注模型,给药组给予补阳还五汤原方剂量的水煎液,每日一次,连续灌胃7d;模型组与假手术组均给予同体积生理盐水。测定SOD、GST和GSH-PX活性以及血清中MDA含量。结果:补阳还五汤可以显著提高脑缺血再灌注大鼠SOD、GST、GSH-PX的活性,明显抑制MDA的生成。结论:补阳还五汤对脑缺血再灌注损伤具有明显的保护作用,抗氧化作用是其发挥脑缺血保护作用的机制之一。
Objective To investigate the protection and mechanism of Buyang huanwu tang on focal cerebral in rats.Methods Fo-cal cerebral ischemia -reperfusion model was made with sutur -occluded method in rats.Dose group was given Buyang huanwu tang, Model group and Sham group were given physiological saline.Then they were given once a day for seven consecutive days.The vol-ume of cerebral in farction,the level of MDA in serum,the activities of SOD 、GST and GSH -Px in serum were rileasured.Results Buyang huanwu tang could increase the activities of SOD、GST and GSH -Px in serum and decrease MDA level.Conclosion Buyang huanwu tang has significant protection again cerebral ischemia -reperfusion injury.This effect may be related to its antioxidant proper-ty.
出处
《中国民族民间医药》
2015年第1期42-43,共2页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
福建省中医药研究院自主选题(2012fjzzyk-4)资助项目
