摘要
以叠氮糖、炔丙基溴和鹰嘴豆芽素A为原料,利用"Click chemistry"将糖基化三氮唑药效基团与鹰嘴豆芽素A巧妙结合,得到4种新的标题化合物,产物结构经1HNMR、13CNMR、IR、EI-MS和元素分析确认。通过小鼠常压密闭耐缺氧模型对其药理活性进行评价,结果表明:4个目标化合物均不同程度地延长小鼠的存活时间,其中半乳糖苷三氮唑鹰嘴豆芽素A和木糖苷三氮唑鹰嘴豆芽素A的活性优于乙酰唑胺。
Four newchrysin derivatives linked with glycosyltriazole using the glucose,propargyl bromide and biochanin A as starting materialwere synthesized via ＂Click chemistry＂. The structure was confirmedby1 HNMR,13CNMR,IR,EI-MS and elemental analysis. The anti-hypoxic activities of four compounds were examined using the normobaric hypoxia model of mice. Compared to the model group,fourchrysin derivatives can enhanced the survival time of mice in hypoxia. The anti-hypoxia activity of galactopytriazole biochanin A and xylosyltriazole biochanin A were better than that of acetazolamide.
出处
《化学试剂》
CAS
北大核心
2015年第1期13-17,52,共6页
Chemical Reagents
基金
国家自然科学基金资助项目(81202458)
全军医药科研"十二五"面上基金资助项目(CLZ12JA04)
中国博士后科学基金资助项目(2012M521926)
