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AIRE基因与重症肌无力、胸腺瘤关系的研究进展 被引量：1

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摘要 自身免疫调节因子(autoimmune regulator,AIRE)是一种具有转录活化潜能的结合蛋白,该基因在生理状态之下可能对维持自身免疫耐受起关键作用。重症肌无力患者中有75%胸腺异常,其中15%表现为胸腺瘤。95%胸腺瘤中AIRE基因表达缺失,该文对AIRE基因、重症肌无力及胸腺瘤之间的关系作一综述。
作者 郑神英 田云霄
机构地区 河北省邯郸市中心医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2014年第12期1403-1406,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 自身免疫调节因子 重症肌无力 胸腺瘤 免疫耐受
分类号 R730.23 [医药卫生—肿瘤]
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  • 1Betterle C, Greggio NA, Volpato M. Clinical review 93: autoimmune polyglandular syndrome type Ⅰ[J]. J Clin Endocrinol Metab, 1998, 83:1049-1055. 被引量：1
  • 2Aahonen J, Bjorses P, Perheentupa J, et al. An autoim mune disease, APECED, caused by mutations in a novel gene feamring two PHD-type zinc finger domains[J] Nat Genet, 1997, 17:399-403. 被引量：1
  • 3Nagamine K, Peterson P, Scott HS, et al. Positional cloning of the APECED gene[J]. Nat Genet, 1997, 17:393-398. 被引量：1
  • 4Mathis D, Benoist C. Aire[J]. Annu Rev Immunol, 2009, 27:287-312. 被引量：1
  • 5Klamp T, Sahin U, Kyewski B, et al. Expression profile of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues[J]. Immunol Lett, 2006, 106:172-177. 被引量：1
  • 6Wang CY, Shi JD, Davoodi Semiromi A, et al. Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syn- drome type 1 (ASP1)[J]. Genomics, 1999, 55:322-336. 被引量：1
  • 7Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self shadow within the thymus by the aire protein[J]. Science, 2002, 298:1395-1401. 被引量：1
  • 8Ramsey C, Winqvist O, Puhakka I., et al. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response[J]. Hum Mol Genet, 2002, 11: 397-409. 被引量：1
  • 9Kuroda N, Mitani T, Takeda N, et al. Development of au toimmunity against transcriptionally unrepressed target anti gen in the thymus of Aire deficient mice[J]. J Immunol, 2005. 174:1862-1870. 被引量：1
  • 10Hubert FX, Kinkel SA, CrewtherPE, et al. Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype[J]. J Immunol, 2009, 182:3902-3918. 被引量：1

共引文献37

同被引文献13

  • 1Travis WD,Brambilla B,Harris CC,et al.肺、胸膜、胸腺及心脏肿瘤病理学和遗传学[M].孟字宏,张建中,主译.北京:人民卫生出版社,2006:83-88. 被引量：18
  • 2Samani A A, Brodt P. The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis [ J]. Surg Oncol Clin N Am, 2001,10(2) :289 -312. 被引量：1
  • 3Aisner S C, Dahlberg S, Hameed M R, et al. Epidermal growth factor receptor, C-kit, and Her2/neu immunostaining in advanced or recurrent thymic epithelial neoplasms staged according to the 2004 World Health Organization in patients treated with octreotide and prednisone: an eastern cooperative oncology group study[ J]. J Thorac Oncol, 2010,5 (6) :885 - 92. 被引量：1
  • 4Ionescu D N, Sasatomi E, Cieply K, et al. Protein expression and gene amplification of epidermal growth factor receptor in thymomas [J]. Cancer, 2005,103(3):630-6. 被引量：1
  • 5Mitsudomi T, Yatabe Y. Epidermal growth factor receptor in rela- tion to tumor development: EGFR gene and cancer [ J ]. FEBS ], 2010,277 (2) :301 - 8. 被引量：1
  • 6Omatsu M, Kunimura T, Mikogami T, et al. hnmunohistochemi- cal analysis of thymic carcinoma focusing on the possibility of mo- lecular targeted and hormonal therapies [ J ]. Gen Thorac Cardio- vasc Surg, 2012, 60(12) :803- 10. 被引量：1
  • 7Grimberg A. Mechanisms by which IGF-I may promote cancer 3. Cancer Bio[ Ther, 2033,2(6) :630 -5. 被引量：1
  • 8Hartog H, Wesseling J, Boezen H M, et al. The insulin-like growth factor l receptor in cancer: old focus, new future[ J]. Eur J Cancer, 2007,43 ( 13 ) : 1895 - 904. 被引量：1
  • 9Girard N, Teruya-Feldstein J, Payabyab E C, et al. Insulin-like growth factor-1 receptor expression in thymic malignancies [ J ]. Thorae Oncol, 2010,5(9) :1439 -46. 被引量：1
  • 10King E R, Wong K K. Insulin-like growth factor: current concepts and new developments in cancer therapy[ J]. Recent Pat Anfican- cer Drug Discov, 2012,7 ( 1 ) : 14 - 30. 被引量：1

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临床与实验病理学杂志
2014年 第12期

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