摘要
目的 探讨早产小于胎龄儿（SGA）与适于胎龄儿（AGA）在振幅整合脑电图（aEEG）图形评分上的差异.方法 选择2013年3月至2014年2月入住广东医学院附属医院儿童医学中心新生儿重症监护室的早产儿139例,符合纳入标准的32～36周的早产儿114例,其中SGA组54例,AGA组60例.采用Nico-letOne脑功能监护仪,均于出生3d内进行监测,每次连续监测至少3h.运用早产儿aEEG评分系统,对比分析2组早产儿在aEEG图形连续性、睡眠-觉醒周期、下边界振幅、带宽和总评分各参数分值间的差异.结果 1.随着出生胎龄的增加,SGA组aEEG图形的连续性、睡眠-觉醒周期、下边界振幅、带宽和总评分分值均逐渐增加,不同胎龄组间的差异有统计学意义（P均＜0.05）;AGA组aEEG图形睡眠-觉醒周期、带宽和总评分也逐渐增加,不同胎龄组间比较差异均有统计学意义（P均＜0.05）,但连续性、下边界振幅其不同胎龄组间的差异均无统计学意义（P均＞0.05）.2.SGA组连续性、睡眠-觉醒周期、下边界振幅、带宽和总评分均与出生胎龄有相关性（r=0.438、0.597、0.385、0.606、0.608,P均＜0.05）;AGA组睡眠-觉醒周期、带宽和总评分与出生胎龄有相关性（r=0.528、0.615、0.635,P均＜0.05）.3.相同出生胎龄下,SGA组在带宽评分和总评分方面落后于AGA组.结论 睡眠-觉醒周期、带宽和总评分均可作为早产SGA与AGA脑成熟度的评估指标,而相同出生胎龄下,SGA在带宽和总评分方面的落后可能与其神经发育迟缓有关。
Objective To compare the scores of amplitude-integrated electroencephalogram （aEEG） tracings between preterm infants who were smaller for gestational age （SGA） and those who were appropriate for gestation （AGA）.Methods A total of 139 preterm infants were collected in the Neonatal Intensive Care Unit of the Affiliated Hospital of Guangdong Medical College during the period of Mar.2013 to Feb.2014.One hundred and fourteen patients met the inclusion criteria with gestational ages from 32 to 36 weeks at birth,including 54 SGA infants and 60 AGA infants.The aEEG recordings were obtained within 72 h after birth by using the NicoletOne monitor.Duration of each recording was at least 3 h.Five aspects of each tracing,such as continuity （Co）,sleep-wake cycling （Cy）,amplitude of the lower border （LB）,bandwidth （B） and total maturation scores,were evaluated and compared between 2 groups by applying a aEEG scoring system.Results 1.As SGA infants,scores for Co,Cy,LB,B as well as total maturation scores were progressively increased with gestational age advancing（all P ＜ 0.05）.As AGA infants,scores for Cy,B and total maturation scores progressively increased with advancing gestational age （all P ＜ 0.05）,but there were no statistical differences between each gestational ages in Co,LB scores （all P ＞ 0.05）.2.Linear regression analysis of SGA infants＇ gestational age to Co,Cy,LB,B and total maturation scores showed positively correlation,and the correlation coefficients were 0.438,0.597,0.385,0.606 and 0.608,respectively （all P ＜ 0.05）.As AGA infants,a positive correlation between gestational age and Cy,B as well as total maturation scores were observed,and the correlation coefficients were 0.528,0.615 and 0.635,respectively （all P ＜ 0.05）.3.At the same gestational age,both the B scores and total maturation scores in SGA group were lower than those in AGA group.Conclusions SGA and AGA,Co,Cy and total maturation scores can be used to evaluate the maturation of cerebral func
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2014年第24期1870-1873,共4页
Chinese Journal of Applied Clinical Pediatrics
关键词
振幅整合脑电图
脑功能监测
早产儿
小于胎龄儿
适于胎龄儿
成熟评分
Amplitude-integrated electroencephalogram
Cerebral function monitoring
Pretrem infant
Small for gestational age
Appropriate for gestational age
Maturation score
