摘要
目的 探讨汉族人抗核基质蛋白2（NXP2）抗体阳性多发性肌炎/皮肌炎（PM/DM）患者的临床特点.方法 采用免疫沉降-蛋白印迹法对141例汉族成人PM/DM患者进行抗NXP2抗体检测,收集阳性患者的临床资料进行回顾性分析,复习国内外文献并与之比较.采用x2检验和Fisher确切概率法进行统计学处理.结果 共有7例（5％）患者抗NXP2抗体阳性,其中DM患者6例,PM患者1例.和文献报道的114例抗NXP2阳性患者类似,汉族抗NXP2阳性患者多有肌无力、向阳疹和Gottron征.与抗体阴性患者相比,抗体阳性患者吞咽困难[43％（3/7）和9％（12/134）,χ^2=8.04,P=0.027）]和肢体肿胀[（43％（3/7）和2％（3/134）,χ^2=26.94,P=0.001 4）]的发生率较高.未发现明显恶性肿瘤相关性.结论 在汉族成人中,抗NXP2抗体主要见于DM,患者吞咽困难和肢体肿胀的发生率较高.
Objective To investigate the clinical features of polymyositis/dermatomyositis （PM/DM） with anti-nuclear matrix protein （anti-2NXP2） antibodies in Han-Chinese.Methods ImmunoprecipitationWestern Blotting （IP-WB） method was used for screening anti-NXP2 antibodies in 141 adult Han-Chinese patients with PM/DM.The clinical and laboratory data were collected,analyzed and compared with the antiNXP2-positive patients reported in the literature.Statistical analyses were performed using chi-square test and Fisher＇s exact test.Results Seven （5%） patients,including 6 with DM and 1 with PM,were identified as anti-NXP2 positive.Consistent with the 114 anti-NXP2-positive patients reported in the literature,Han patients with anti-NXP2 had higher frequencies of weakness,heliotrope rash and Gottron＇s sign.Compared with anti-NXP2-negative patients,anti-NXP2-positive patients presented significantly higher frequencies of dysphagia [43%（3/7） vs 9%（12/134）,χ^2=8.04,P=0.027] and edema [43%（3/7） vs 2%（3/134）,χ^2=26.94,P=0.001 4],while an absence of PM/DM related cancer was observed in Han patients with anti-NXP2.Conclusion Adult Han-Chinese patients with anti-NXP2 are DM predominant,and are characterized by a high frequencies of edema and dysphagia.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2014年第12期810-814,共5页
Chinese Journal of Rheumatology
基金
国家自然科学基金（81302556）
南京市医学科技发展基金
关键词
多发性肌炎
皮肌炎
肺疾病
间质性
抗核基质蛋白2抗体
Polymyositis
Dermatomyositis
Lung disease,interstitial
Anti-nuclear matrix protein antibody
