摘要
目的研究瑞舒伐他汀(RSVT)对急性冠状动脉综合征(ACS)患者行经皮冠状动脉介入治疗术(PCI)后血管内皮功能(VEF)、血清炎症因子(IF)以及预后的影响。方法选择该院2010年7月至2013年7月80例行PCI术的ACS病患进行观察,分为观察组和对照组,每组40例。观察组给予RSVT干预治疗,对照组给予常规治疗。对比两组VEF、IF以及预后情况。结果观察组术后4周VWF为(92.6±12.3)%、ET-1为(55.6±5.6)ng/L;较对照组术后4周的(105.4±13.6)%、(67.8±7.4)ng/L明显更低;观察组术后4周NO为(78.6±9.4)μmol/L,较对照组术后4周的(63.2±9.5)μmol/L明显更高。观察组PCI术后4周CRP为(5.4±2.2)mg/L,较对照组的(10.5±4.1)mg/L明显更低。观察组CVE发生率为5.00%(2/40)、再狭窄率为2.50%(1/40)明显较对照组的30.00%(12/40)、10.00%(4/40)更低,差异有统计学意义(均P<0.05)。结论 RSVT能够有效改善ACS病患PCI术后VEF,减少炎性反应,降低CVE以及再狭窄的发生概率。
Objective To study the effect of rosuvastatin（RSVT） on the vascular endothelial function（VEF） ,inflammatory fac-tors（IF） and prognosis in patients with acute coronary syndrome （ACS） after percutaneous coronary intervention（PCI） .Methods Eighty cases of ACS patients with PCI in our hospital selected from July 2010 to July 2013 were randomly divided into observed group and control group ,40 cases in each group .The observation group were given interference treatment with RSVT while the control group received conventional treatment .The VEF ,IF and prognosis were compared between groups .Results The VWF at 4 weeks after PCI in observation group was lower than that in control group [（92 .6 ± 12 .3）% vs .（105 .4 ± 13 .6）% ,P〈0 .05];The ET-1 at 4 weeks after PCI in observation group was lower than that in control group[（55 .6 ± 5 .6）ng/L vs .（67 .8 ± 7 .4）ng/L ,P〈0 .05] .The NO at 4 weeks after PCI in observation group was higher than that of control group[（78 .6 ± 9 .4）μmol/L vs .（63 .2 ± 9 .5）μmol/L ,P〈0 .05] .The CRP at 4 weeks after PCI in observation group was lower than that in control group[（5 .4 ± 2 .2） mg/L vs .（10 .5 ± 4 .1）mg/L ,P〈0 .05] .The incidence of CVE was 5 .00% （2/40） ,restenosis rate was 2 .50% （1/40） in observa-tion group ,which was significantly lower than those of the control group [30 .00% （12/40） ,10 .00% （4/40）] ,the differences were statistically significant（P〈0 .05） .Conclusion RSVT could effectively improve the VEF and reduce inflammation ,CVE and rest-enosis rate in patients with ACS after PCI .
出处
《重庆医学》
CAS
北大核心
2015年第1期52-54,共3页
Chongqing medicine
