摘要
目的研究脑梗死患者血浆同型半胱氨酸(Hcy)、纤维蛋白原(Fib)水平改变及其与病情和预后的相关性。方法检测250例脑梗死患者和100名健康者的血浆Hcy、Fib水平。在患者入院当天进行美国国立卫生研究院卒中量表(NHISS)评定,并在随访6月后进行改良Rankin量表评价。结果脑梗死组患者血浆Hcy、Fib水平明显高于健康对照组(P<0.05);NHISS重度患者血浆Hcy、Fib水平明显高于中度、轻度患者(P<0.05);中度患者血浆Hcy、Fib水平显著高于轻度患者(P<0.05)。低Hcy、Fib组脑梗死患者预后良好率显著高于高Hcy、Fib组(P<0.05)。结论脑梗死患者血浆Hcy、Fib水平明显升高,病情重的患者升高更明显。血浆Hcy、Fib水平升高的患者预后相对较差。
Objective To study the correlation between the change of .plasma homocysteine （Hcy） and fibrinogen（Fib） levels with the disease condition and prognosis in the patients with cerebral infarction（CI）. Methods The plasma levels of Hcy and Fib were detected in 250 cases of cerebral infarction and 100 healthy adults（normal control,NC）. All patients were evaluated on 1 d after admission by NHISS,and after the 6-month follow-up by the modified Rankin scale. Results The levels of plasma Hcy and Fib in the CI group were significantly higher than those in the NC group（P〈0.05）;the levels of plasma Hcy and Fib in the NHISS se- vere patients were higher than those in the moderate and mild patients （P〈0.05） ;the levels of plasma Hey and Fib in the moderate patients were significantly higher than those in the mild patients （P〈0.05）. The good prognosis rate the low Hey and Fib group was significantly higher than that in high Hcy and Fib group （P〈0.05）. Conclusion The levels of plasma Hcy and Fib are signifi- cantly increased in the patients with CI,and the increase in the severe patients is more significant. The patients with increased plas- ma Hcy and Fib levels have relatively poor prognosis.
出处
《国际检验医学杂志》
CAS
2015年第1期55-56,59,共3页
International Journal of Laboratory Medicine
关键词
同型半胱氨酸
血浆纤维蛋白
脑梗死
预后
homocysteine
plasma fibrinogen
cerebral infarction
prognosis
