摘要
目的：探讨血清胆红素（TBil）水平与老年2型糖尿病（T2DM）颈动脉内膜中层厚度（CIMT）关系。方法选择2012年7月～2013年10月十堰市太和医院收治的102例老年2型糖尿病患者，根据颈动脉内膜中层厚度分为CIMT增厚组（54例）和CIMT正常组（48例），分别测定血清TBil水平及体重指数（BMI）、血压、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）等，并结合临床资料进行分析。结果 CIMT增厚组病程显著长于CIMT正常组，LDL-C显著高于CIMT正常组，TBil显著低于CIMT正常组，差异均有统计学意义（均P＜0.05）。 TBil与CIMT呈负相关（r=-0.204，P＜0.05）。 Logistic回归分析显示：病程、LDL-C、TBil是CIMT增厚的独立危险因素（OR =1.121，4.753、0.743，均P＜0.05）。结论胆红素水平是老年T2DM患者CIMT增厚的独立危险因素，CIMT增厚患者胆红素水平降低。
Objective To explore the relationship between the serum levels of bilirubin and intima-media thickness of carotid artery in old patients with type 2 diabetes mellitus. Methods From July 2012 to October 2013, in Taihe Hospi-tal of Shiyan City, 102 old patients with type 2 diabetes were devided into CIMT normal group （48 cases） and CIMT thickened group （54 cases）, according to the carotid intima-media thickness （CIMT）. Serum total bilirubin （TBil）, body mass index （BMI）, blood pressure, lipid profiles （TG, HDL-C, LDL-C）, fasting plasma glucose （FBG）, fasting insulin （FINS ） and HbA1c of two groups were meaured and analyzed. Results The level of TBil in CIMT thickened group was lower than that in CIMT normal group, desease course in CIMT thickened group was longer than that in CIMT normal group, LDL-C in CIMT normal group was significantly higher than those in CIMT thickened group, the differences were statistically significant （P〈 0.05）. The level of serum bilirubin was negatively associated with CIM （r = -0.204, P〈0.05）. Logistic regression analysis showed that desease course , LDL-C, TBil were independently correlated with CIMT （OR = 1.121, 4.753, 0.743, all P〈 0.05）. Conclusion The level of serum bilirubin independently and negatively asso-ciated with CIMT in old patients with type 2 diabetes mellitus.
出处
《中国医药导报》
CAS
2015年第1期56-58,共3页
China Medical Herald
关键词
胆红素
2型糖尿病
颈动脉
内膜中层厚度
Bilirubin
Type 2 diabetes mellitus
Carotid artery
Intima-media thickness
