摘要
目的：分析伊曲康唑对难治性复发性真菌性外耳道炎的临床疗效。方法：研究对象为赣南医学院第一附属医院2011年1月—2013年1月间收治的208例难治性复发性真菌性外耳道炎患者,采用抽签法将上述患者分为观察组与对照组各104例,两组均给予3%水杨酸乙醇液清洗,观察组患者在此基础上给予加用口服伊曲康唑治疗,比较两组患者治疗后的临床疗效及其复发率、治愈率和不良反应的出现率。结果：观察组患者经分别治疗1,2,3疗程,其各疗程的有效率86.54%,91.35%和99.04%显著高于对照组52.88%,73.08%和84.62%（P〈0.05）;经治疗1年后随访其患者无复发病例,不良症状出现率低于对照组（P〈0.05）。结论：伊曲康唑具有疗效显著、安全性高、复发率低等诸多优势,其对治疗难治性复发性真菌性外耳道炎时应作为首选药物。
Objective： To analyze the clinical efficacy of itraconazole in patients with refractory recurrent fungal otitis externa. Methods： This study in our hospital was conducted from January 2011 to January 2013 in 208 cases of refractory and relapse of fungal otitis externa patients, in order to develop a drawing method the patients were divided into observation group and control group, Two groups were given 3% salicylic acid and alcohol cleaning. On this basis of the observation group was given oral itraconazole therapy. The two grops were compared in the cure rate, recurrence rate and adverse reaction rate. Results： 3 cycles of efficiency were 86.54%, 91.35% and 99.04%, respectively. The difference was statistically significant （P〈0.05）. In the patients of the observation group the effective rate was significantly higher than the control group. After 1 years of treatment follow-up no recurrence and adverse symptoms were significantly lower than those of the control group. The difference was statistically significant （/）〈0.05）. Conclusion： Itraconazole has the advantages of clinical efficacy, high safety, high safely. Low recurreen ce rate. It may be used in the treatment of refractory funsal otitis externals.
出处
《抗感染药学》
2014年第5期472-474,共3页
Anti-infection Pharmacy
