摘要
精氨酸在一氧化氮合酶的催化作用下生成NO,进而调节组织器官的脂类代谢,促进了葡萄糖和脂肪酸的氧化分解以及脂肪细胞的脂解作用,抑制脂肪的组织沉积,其作用机制可能与NO的c AMP信号通路对脂类代谢相关酶的活性、基因表达以及信号转导的调节有关。文章综述了一氧化氮合酶的分布和结构特征,精氨酸对脂类代谢的调节作用,并且探讨了精氨酸调节脂类代谢的可能机制。
Arginine produces nitric oxide under the catalysis of nitric oxide synthase, and then regulates the lipid metabolism of tissues and organs, promoting the glucose and fatty acid oxygenolysis and the fat cells lipolysis, inhibiting the adipose tissue deposition. Its mechanism may be associated with the regulation of the cAMP signaling pathways of nitric oxide on lipid metabolism related enzyme activity, gene expression and signal transduction. This context summarizes the distribution and structure characteristics of nitric oxide synthase and the arginine regulation of lipid metabolism, and then discusses the possible mechanisms of arginine regulating lipid metabolism.
出处
《饲料工业》
北大核心
2014年第24期40-46,共7页
Feed Industry
关键词
精氨酸
NO
脂类代谢
葡萄糖代谢
线粒体呼吸
arginine
NO
lipid metabolism
glucose metabolism
mitochondrial respiration
