摘要
颗粒蛋白前体(PGRN)是一个多功能生长因子,其对调节和维护机体正常组织的发展、增殖、再生及防御稳态发挥重要作用。PGRN与感染、免疫、炎症这三个紧密相关的病理生理过程密切相关。最近,PGRN对免疫信号转导通路,特别是肿瘤坏死因子受体的影响倍受瞩目。预期PGRN对临床上种类繁多的炎症性疾病具有巨大的治疗潜力。
Progranulin（ PGRN ） , a multifunctional growth factor, is known to play an important role in the regulation and maintenance of the homeostatic dynamics of the body, such as development, proliferation, regeneration, and the host-defense response of normal tissues. PGRN is closely associated with three pathophysiological processes which is infection, immunity, inflammation respectively. Recent study has shown that it greatly influences on the immune signal transduction pathway, especially on TNF/TNFR. Therefore, PGRN has great potential in treating various inflammatory diseases in clinical practice.
出处
《医学综述》
2014年第24期4445-4448,共4页
Medical Recapitulate
关键词
颗粒蛋白前体
肿瘤坏死因子Α
免疫
感染
炎症
Progranulin
Tumor necrosis factor α
Immunity
Infection
Inflammation
