摘要
以水杨醛和丙二酸二乙酯为起始原料,经Knoevenagel缩合反应合成香豆素-3-羧酸乙酯,再经水解、酸化得到香豆素-3-羧酸,然后与新蒸的亚硫酰氯反应生成香豆素-3-甲酰氯,超声辅助KI催化,再与单取代哌嗪反应,合成了含有香豆素基和哌嗪两种生物活性基团的新化合物,并对中间体和目标产物的结构进行了表征。结果表明,设计的技术路线合理,反应条件温和,目标产物收率高,成本低,有较好的开发应用前景。
In this paper, coumarin-3-carboxylic acid ethyl ester was synthesized by Knoevenagel condensation reaction using salicylaldehyde and diethyl malonate as the raw material, and then eoumarin -3-formic acid was synthesized by hydrolysis and acidification of coumarin-3- carboxylic acid ethyl ester, the reaction of coumarin-3-formic acid with new steamed thionyt chloride yielded counrarin-3-chloride, coumarin-3-chloride was reacted under ultrasound with single instead of piperazine to yield N-benzyl-N＇-coumarin-3-formyl piperazine. Those compounds were characterized by IR, GC-MS and NMR analysis.
出处
《中兽医医药杂志》
2014年第6期12-14,共3页
Journal of Traditional Chinese Veterinary Medicine
基金
国家自然科学基金(21262010)
河西学院校长科研基金(XZ2011-07)
关键词
香豆素-3-甲酸
哌嗪
苄氯
超声
coumarin-3-formic acid
piperazine
benzyl chloride
ultrasound
